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• W2088355344 abstract "A novel series of spirochromane pan-Akt inhibitors is reported. SAR optimization furnished compounds with improved enzyme potencies and excellent selectivity over the related AGC kinase PKA. Attempted replacement of the phenol hinge binder provided compounds with excellent Akt enzyme and cell activities but greatly diminished selectivity over PKA." @default.
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• W2088355344 date "2011-04-01" @default.
• W2088355344 modified "2023-10-08" @default.
• W2088355344 title "Discovery and SAR of spirochromane Akt inhibitors" @default.
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• W2088355344 doi "https://doi.org/10.1016/j.bmcl.2011.02.073" @default.
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