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• W2088356727 abstract "It is generally believed that neutrophils from HIV-infected patients are functionally competent, but several studies have shown impairment in neutrophil fungal killing and cytokine production. In this study we evaluated the ability of neutrophils from healthy donors and HIV-infected patients to produce IL-12 in response to stimulation with Candida albicans, lipopolysaccharide (LPS) and Cryptococcus neoformans (acapsular and encapsulated), with and without MoAb opsonization. Neutrophils from healthy donors secreted IL-12 in response to LPS or C. albicans but not in response to encapsulated or acapsular C. neoformans, regardless of MoAb opsonization. Surprisingly, neutrophils from HIV-infected patients demonstrated constitutive IL-12 production, although these cells were not responsive to LPS stimulation. The inability of MoAb to C. neoformans capsular polysaccharide to promote IL-12 production by neutrophils excludes phagocytosis and/or CD16 cross-linking in this process, and distinguishes neutrophils from monocytes. Our results provide additional evidence for cytokine dysregulation in neutrophils from HIV-infected patients. Furthermore, the IL-12 response of neutrophils and monocytes to CD16 stimulation appears to be different, suggesting differences in the role of these phagocytic cells during the inflammatory response." @default.
• W2088356727 created "2016-06-24" @default.
• W2088356727 creator A5032197333 @default.
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• W2088356727 creator A5051777748 @default.
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• W2088356727 date "2000-08-01" @default.
• W2088356727 modified "2023-09-28" @default.
• W2088356727 title "Dysregulation in IL-12 secretion by neutrophils from HIV-infected patients" @default.
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• W2088356727 doi "https://doi.org/10.1046/j.1365-2249.2000.01278.x" @default.
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