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• W2088362013 endingPage "11788" @default.
• W2088362013 startingPage "11784" @default.
• W2088362013 abstract "The pathogenesis of progressive spastic paraparesis [HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP)], a serious consequence of human T-cell leukemia virus type I (HTLV-I) infection, is unclear. T and B lymphocytes can be naturally infected by HTLV-I, but the susceptibility to HTLV-I infection of other cell types that could contribute to the pathogenesis of HAM/TSP has not been determined. We found that a human monocyte cell line (THP-1), primary human peripheral blood monocytes, and isolated microglial cells but not astrocytes or oligodendroglial cells derived from adult human brain were infected by HTLV-I in vitro. Infection with HTLV-I enhanced the secretion of interleukin 6 in human microglial cell-enriched cultures but did not stimulate the release of interleukin 1 from monocytes or microglial cells. Tumor necrosis factor alpha production was stimulated by HTLV-I infection of monocytes and microglial cells and could be enhanced by suboptimal amounts of lipopolysaccharide. Since both tumor necrosis factor alpha and interleukin 6 have been implicated in inflammatory demyelination and gliosis, our findings suggest that human microglial cells and monocytes infected with and activated by HTLV-I could play a role in the pathogenesis of HAM/TSP." @default.
• W2088362013 created "2016-06-24" @default.
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• W2088362013 date "1992-12-15" @default.
• W2088362013 modified "2023-09-27" @default.
• W2088362013 title "Human T-cell leukemia virus type I infection of monocytes and microglial cells in primary human cultures." @default.
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• W2088362013 doi "https://doi.org/10.1073/pnas.89.24.11784" @default.
• W2088362013 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/50641" @default.
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