FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088371567> ?p ?o ?g. }

• W2088371567 endingPage "568" @default.
• W2088371567 startingPage "564" @default.
• W2088371567 abstract "Neutrophils are thought to play a role in the pathogenesis of inflammatory bowel diseases (IBD) such as ulcerative colitis and Crohn's disease, since prominent neutrophil infiltration has been observed in the inflamed colonic mucosa of patients with IBD. However, the role of neutrophils in the pathogenesis of IBD and experimental colitis remains equivocal. The aim of the present study is to clarify the possible role of neutrophils in the progression of acetic acid-induced colitis in mice.Using neutropenic mice treated with cyclophosphamide or with an LTB4 receptor antagonist, ONO-4057, the relationship between the severity of macroscopic colonic damage, the extent of myeloperoxidase (MPO) activities in the colonic tissues, and the number of neutrophils in the blood were examined after induction of colitis in mice.Changes of MPO activity in the colonic tissues paralleled well with the severity of the mucosal damage. In spite of a significant reduction in the number of neutrophils in the blood in cyclophosphamide-treated mice, neither the severity of mucosal damage in the colon nor the increase in MPO activities in the colonic tissues was affected 24 h after induction of colitis. Treatment with ONO-4057 significantly suppressed both the severity of mucosal damage in the colon and MPO activities in the colonic tissues in acetic acid-induced colitis in mice.The present results, obtained using treatment with cyclophosphamide and ONO-4057, show that the severity or the progression of acetic acid-induced colitis in mice was not influenced by a reduction of circulating neutrophils to about 25% of base line." @default.
• W2088371567 created "2016-06-24" @default.
• W2088371567 creator A5005443263 @default.
• W2088371567 creator A5008677045 @default.
• W2088371567 creator A5027451519 @default.
• W2088371567 date "1997-01-01" @default.
• W2088371567 modified "2023-10-14" @default.
• W2088371567 title "Evaluation of the Role of Neutrophils in the Pathogenesis of Acetic Acid-Induced Colitis in Mice" @default.
• W2088371567 cites W1737586041 @default.
• W2088371567 cites W184167452 @default.
• W2088371567 cites W1878840569 @default.
• W2088371567 cites W1991592255 @default.
• W2088371567 cites W2020358486 @default.
• W2088371567 cites W2022594329 @default.
• W2088371567 cites W2032523931 @default.
• W2088371567 cites W2064009840 @default.
• W2088371567 cites W2083285179 @default.
• W2088371567 cites W2084971617 @default.
• W2088371567 cites W2130244415 @default.
• W2088371567 cites W2138585310 @default.
• W2088371567 cites W2144674922 @default.
• W2088371567 cites W2166525518 @default.
• W2088371567 cites W2322570099 @default.
• W2088371567 cites W2417586332 @default.
• W2088371567 cites W315764148 @default.
• W2088371567 cites W4214589643 @default.
• W2088371567 cites W4254679467 @default.
• W2088371567 cites W4379136709 @default.
• W2088371567 cites W51133436 @default.
• W2088371567 doi "https://doi.org/10.3109/00365529709025100" @default.
• W2088371567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9200288" @default.
• W2088371567 hasPublicationYear "1997" @default.
• W2088371567 type Work @default.
• W2088371567 sameAs 2088371567 @default.
• W2088371567 citedByCount "25" @default.
• W2088371567 countsByYear W20883715672013 @default.
• W2088371567 countsByYear W20883715672014 @default.
• W2088371567 countsByYear W20883715672015 @default.
• W2088371567 countsByYear W20883715672016 @default.
• W2088371567 countsByYear W20883715672017 @default.
• W2088371567 countsByYear W20883715672018 @default.
• W2088371567 countsByYear W20883715672019 @default.
• W2088371567 crossrefType "journal-article" @default.
• W2088371567 hasAuthorship W2088371567A5005443263 @default.
• W2088371567 hasAuthorship W2088371567A5008677045 @default.
• W2088371567 hasAuthorship W2088371567A5027451519 @default.
• W2088371567 hasConcept C121332964 @default.
• W2088371567 hasConcept C126322002 @default.
• W2088371567 hasConcept C142724271 @default.
• W2088371567 hasConcept C153400128 @default.
• W2088371567 hasConcept C185592680 @default.
• W2088371567 hasConcept C198677920 @default.
• W2088371567 hasConcept C203014093 @default.
• W2088371567 hasConcept C203565725 @default.
• W2088371567 hasConcept C2775862500 @default.
• W2088371567 hasConcept C2776673659 @default.
• W2088371567 hasConcept C2776694085 @default.
• W2088371567 hasConcept C2776755627 @default.
• W2088371567 hasConcept C2776914184 @default.
• W2088371567 hasConcept C2778260677 @default.
• W2088371567 hasConcept C2779134260 @default.
• W2088371567 hasConcept C2780479503 @default.
• W2088371567 hasConcept C2780942790 @default.
• W2088371567 hasConcept C55493867 @default.
• W2088371567 hasConcept C71924100 @default.
• W2088371567 hasConcept C90924648 @default.
• W2088371567 hasConcept C97355855 @default.
• W2088371567 hasConceptScore W2088371567C121332964 @default.
• W2088371567 hasConceptScore W2088371567C126322002 @default.
• W2088371567 hasConceptScore W2088371567C142724271 @default.
• W2088371567 hasConceptScore W2088371567C153400128 @default.
• W2088371567 hasConceptScore W2088371567C185592680 @default.
• W2088371567 hasConceptScore W2088371567C198677920 @default.
• W2088371567 hasConceptScore W2088371567C203014093 @default.
• W2088371567 hasConceptScore W2088371567C203565725 @default.
• W2088371567 hasConceptScore W2088371567C2775862500 @default.
• W2088371567 hasConceptScore W2088371567C2776673659 @default.
• W2088371567 hasConceptScore W2088371567C2776694085 @default.
• W2088371567 hasConceptScore W2088371567C2776755627 @default.
• W2088371567 hasConceptScore W2088371567C2776914184 @default.
• W2088371567 hasConceptScore W2088371567C2778260677 @default.
• W2088371567 hasConceptScore W2088371567C2779134260 @default.
• W2088371567 hasConceptScore W2088371567C2780479503 @default.
• W2088371567 hasConceptScore W2088371567C2780942790 @default.
• W2088371567 hasConceptScore W2088371567C55493867 @default.
• W2088371567 hasConceptScore W2088371567C71924100 @default.
• W2088371567 hasConceptScore W2088371567C90924648 @default.
• W2088371567 hasConceptScore W2088371567C97355855 @default.
• W2088371567 hasIssue "6" @default.
• W2088371567 hasLocation W20883715671 @default.
• W2088371567 hasLocation W20883715672 @default.
• W2088371567 hasOpenAccess W2088371567 @default.
• W2088371567 hasPrimaryLocation W20883715671 @default.
• W2088371567 hasRelatedWork W1478553671 @default.
• W2088371567 hasRelatedWork W1596258860 @default.
• W2088371567 hasRelatedWork W1965801193 @default.
• W2088371567 hasRelatedWork W1998231725 @default.
• W2088371567 hasRelatedWork W2088371567 @default.

• next