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- W2088377525 abstract "Abstract A rabbit antiserum against the mouse lymphoma EL 4 was rendered EL 4 -specific by exhaustive absorption with syngeneic ( C57BL 6 ) spleen cells. This absorbed serum retained some (complement mediated) cytotoxicity for EL 4 cells; its ability to protect syngeneic mice from tumour challenge is described elsewhere. This serum was used to monitor the extraction and fractionation of the specific antigen of EL 4 cells which is absent from the host mouse. EL 4 cell membranes were solubilized autolytically and by papain digestion and fractionated by gel-filtration and ion-exchange chromatography. By both methods, the EL 4 tumour specific antigen could be separated from H- 2 histocompatibility antigens, in gel filtration by its greater size and in ion-exchange by its higher charge." @default.
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- W2088377525 date "1974-12-01" @default.
- W2088377525 modified "2023-09-25" @default.
- W2088377525 title "Separation of the specific antigen of a mouse lymphoma from histocompatibility antigens" @default.
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- W2088377525 doi "https://doi.org/10.1016/0014-2964(74)90134-0" @default.
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