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- W2088380683 abstract "Study Objective: To present a case of dermatomyositis in a postmenopausal-woman as a paraneoplastyc disorder due to an endometrial adenocarcinoma. Design: Case report and literature review. Setting: Tertiary hospital. South area Madrid. Spain. Patients: One patient. Intervention: Retrospective study. Measurements and Main Results: Edometrial cancer is the second most common gynecologic malignancy in the developed countries. Although the incidence of disease has remained stable, the death rate has increased. Dermatomyositis is an idiopathic inflammatory myopathy. Evidence supports that ocult cancer may be present in up to a 60% of patients with dermatomyositis. Most of the malignancies are located on the genital tract: ovarian, breast and uterus. Clinical prognostic factors that can predict malignancy are elderly age, female sex, cutaneous vasculitis, rapid onset-progress of disease, lack of response to therapy, extended cutaneos lesions and lack of serological abnormalities. We present the case of a postmenopausal woman with dermatomiosytis followed during more than one year, showing lack of response to therapy. Gynaecological ecography was compatible with an endometrial polyp. Although she denied postmenopausal metrorragy a diagnostic hysteroscopy was performed, showing a suspicious-looking mass. The biopsy was compatible with endometrial adenocarcinoma.Deferred pathological findings after surgical treatment reported villoglandular adenocarcinoma G1 Ib N0 Mo. One year and three months after, the patient is free of disease with clinical improvement of the dermatitis. Conclusion: In women with dermatomyositis transvaginal ultrasound is essential because of its simplicity and safety. If we suspect endometrial pathology, in the presence of abnormal metrorrhagia or if there is no improvement with treatment an hysteroscopy must be performed to assess the endocervical canal and uterine cavity." @default.
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- W2088380683 date "2009-11-01" @default.
- W2088380683 modified "2023-10-18" @default.
- W2088380683 title "Dermatomiosytis: Paraneoplastic Syndrome in a Postmenopausal Woman" @default.
- W2088380683 doi "https://doi.org/10.1016/j.jmig.2009.08.344" @default.
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