Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088382034> ?p ?o ?g. }
- W2088382034 endingPage "181" @default.
- W2088382034 startingPage "173" @default.
- W2088382034 abstract "The most obvious phenotype of Ft/+ mice is a syndactyly of fore limbs characterised by a fusion of the tips of digits 1 to 4. The tempospatial expression of genes involved in limb development revealed that patterning of Ft/+ limb buds is not affected by the mutation. However, an upregulation of Bmp4 in the anterior-distal region of the limb bud at d12.0 of embryonic development is accompanied by a loss of Fgf8 expression in the distal part of the AER. Downstream target genes of Bmp action such as Msx1 and 2 are upregulated. This induction of the signalling cascade indicates ectopic expression of functional Bmp4. Nevertheless, analysis of physical parameters of bones from adult mice revealed a reduction of the bone mass of the autopod. The data suggest a negative effect of Bmp4 on Fgf8 expression and a positive influence on the induction of bone elements." @default.
- W2088382034 created "2016-06-24" @default.
- W2088382034 creator A5035291136 @default.
- W2088382034 creator A5082087707 @default.
- W2088382034 date "1999-11-01" @default.
- W2088382034 modified "2023-09-23" @default.
- W2088382034 title "Syndactyly of Ft /+ mice correlates with an imbalance in Bmp 4 and Fgf 8 expression" @default.
- W2088382034 cites W1575984269 @default.
- W2088382034 cites W1606814949 @default.
- W2088382034 cites W1674638356 @default.
- W2088382034 cites W1754199354 @default.
- W2088382034 cites W1868335994 @default.
- W2088382034 cites W1896587447 @default.
- W2088382034 cites W1937940610 @default.
- W2088382034 cites W1956061573 @default.
- W2088382034 cites W1967380741 @default.
- W2088382034 cites W1971943177 @default.
- W2088382034 cites W1972098727 @default.
- W2088382034 cites W1978596841 @default.
- W2088382034 cites W1979676152 @default.
- W2088382034 cites W1984288177 @default.
- W2088382034 cites W1990787421 @default.
- W2088382034 cites W2007821628 @default.
- W2088382034 cites W2011257584 @default.
- W2088382034 cites W2022446116 @default.
- W2088382034 cites W2023611377 @default.
- W2088382034 cites W2027582069 @default.
- W2088382034 cites W2030245679 @default.
- W2088382034 cites W2033904138 @default.
- W2088382034 cites W2034803929 @default.
- W2088382034 cites W2036570437 @default.
- W2088382034 cites W2038712454 @default.
- W2088382034 cites W2055110202 @default.
- W2088382034 cites W2059532513 @default.
- W2088382034 cites W2060478800 @default.
- W2088382034 cites W2064941027 @default.
- W2088382034 cites W2066479550 @default.
- W2088382034 cites W2068742932 @default.
- W2088382034 cites W2073908723 @default.
- W2088382034 cites W2074354156 @default.
- W2088382034 cites W2090778914 @default.
- W2088382034 cites W2099002558 @default.
- W2088382034 cites W2099229967 @default.
- W2088382034 cites W2099897830 @default.
- W2088382034 cites W2107039126 @default.
- W2088382034 cites W2107141327 @default.
- W2088382034 cites W2122708784 @default.
- W2088382034 cites W2124415162 @default.
- W2088382034 cites W2131820556 @default.
- W2088382034 cites W2132472396 @default.
- W2088382034 cites W2133667440 @default.
- W2088382034 cites W2139203676 @default.
- W2088382034 cites W2150667354 @default.
- W2088382034 cites W2150792687 @default.
- W2088382034 cites W2169314202 @default.
- W2088382034 cites W2185588425 @default.
- W2088382034 cites W2189550019 @default.
- W2088382034 cites W4246928882 @default.
- W2088382034 doi "https://doi.org/10.1016/s0925-4773(99)00186-0" @default.
- W2088382034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10534616" @default.
- W2088382034 hasPublicationYear "1999" @default.
- W2088382034 type Work @default.
- W2088382034 sameAs 2088382034 @default.
- W2088382034 citedByCount "20" @default.
- W2088382034 countsByYear W20883820342012 @default.
- W2088382034 countsByYear W20883820342014 @default.
- W2088382034 countsByYear W20883820342015 @default.
- W2088382034 countsByYear W20883820342021 @default.
- W2088382034 crossrefType "journal-article" @default.
- W2088382034 hasAuthorship W2088382034A5035291136 @default.
- W2088382034 hasAuthorship W2088382034A5082087707 @default.
- W2088382034 hasConcept C104317684 @default.
- W2088382034 hasConcept C105702510 @default.
- W2088382034 hasConcept C126322002 @default.
- W2088382034 hasConcept C127561419 @default.
- W2088382034 hasConcept C127716648 @default.
- W2088382034 hasConcept C134018914 @default.
- W2088382034 hasConcept C145103041 @default.
- W2088382034 hasConcept C170493617 @default.
- W2088382034 hasConcept C196843134 @default.
- W2088382034 hasConcept C25770073 @default.
- W2088382034 hasConcept C2776094402 @default.
- W2088382034 hasConcept C2777202849 @default.
- W2088382034 hasConcept C2780915607 @default.
- W2088382034 hasConcept C2781316418 @default.
- W2088382034 hasConcept C31507581 @default.
- W2088382034 hasConcept C51738704 @default.
- W2088382034 hasConcept C54355233 @default.
- W2088382034 hasConcept C71924100 @default.
- W2088382034 hasConcept C74373430 @default.
- W2088382034 hasConcept C84013057 @default.
- W2088382034 hasConcept C86370654 @default.
- W2088382034 hasConcept C86803240 @default.
- W2088382034 hasConcept C95444343 @default.
- W2088382034 hasConcept C97037327 @default.
- W2088382034 hasConceptScore W2088382034C104317684 @default.
- W2088382034 hasConceptScore W2088382034C105702510 @default.
- W2088382034 hasConceptScore W2088382034C126322002 @default.