Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088382843> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2088382843 abstract "Vascular endothelial growth factor (VEGF) is a multifunctional cytokine which plays a major role in angiogenesis. Alternative splicing causes the production of several different isoforms (VEGF-A 121, 145, 165, 189, 206). VEGF is essential for tumor angiogenesis and several studies have correlated elevated VEGF levels with tumor stage, metastases and progression. Antibody phage display was employed to isolate two scFv antibody fragments, D8 and F10, with specificity for the VEGF165 isoform. It was shown by ELISA and competitive immunohistochemistry that each clone bound to VEGF165 but not VEGF121. Immunohistochemistry with D8 and F10 on colorectal carcinoma and adenoma sections revealed positive staining similar to that shown by a polyclonal VEGF antibody. The scFv antibody fragments, D8 and F10, will be useful in specifically detecting circulating VEGF165 in cancer patients as most studies to date have quantified the total level of circulating VEGF (121 and 165). These reagents will allow further elucidation of the role of VEGF in tumor angiogenesis." @default.
- W2088382843 created "2016-06-24" @default.
- W2088382843 creator A5014880183 @default.
- W2088382843 creator A5017413865 @default.
- W2088382843 creator A5052530924 @default.
- W2088382843 creator A5065908337 @default.
- W2088382843 creator A5066845089 @default.
- W2088382843 creator A5079844729 @default.
- W2088382843 date "2003-02-01" @default.
- W2088382843 modified "2023-09-27" @default.
- W2088382843 title "Isolation and characterisation of vascular endothelial growth factor-165 specific scFv fragments by phage display" @default.
- W2088382843 doi "https://doi.org/10.3892/ijo.22.2.333" @default.
- W2088382843 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12527931" @default.
- W2088382843 hasPublicationYear "2003" @default.
- W2088382843 type Work @default.
- W2088382843 sameAs 2088382843 @default.
- W2088382843 citedByCount "1" @default.
- W2088382843 crossrefType "journal-article" @default.
- W2088382843 hasAuthorship W2088382843A5014880183 @default.
- W2088382843 hasAuthorship W2088382843A5017413865 @default.
- W2088382843 hasAuthorship W2088382843A5052530924 @default.
- W2088382843 hasAuthorship W2088382843A5065908337 @default.
- W2088382843 hasAuthorship W2088382843A5066845089 @default.
- W2088382843 hasAuthorship W2088382843A5079844729 @default.
- W2088382843 hasConcept C121608353 @default.
- W2088382843 hasConcept C153911025 @default.
- W2088382843 hasConcept C159654299 @default.
- W2088382843 hasConcept C167734588 @default.
- W2088382843 hasConcept C186268636 @default.
- W2088382843 hasConcept C203014093 @default.
- W2088382843 hasConcept C204232928 @default.
- W2088382843 hasConcept C2777025900 @default.
- W2088382843 hasConcept C2778690821 @default.
- W2088382843 hasConcept C2780394083 @default.
- W2088382843 hasConcept C2780659158 @default.
- W2088382843 hasConcept C2781018059 @default.
- W2088382843 hasConcept C29537977 @default.
- W2088382843 hasConcept C502942594 @default.
- W2088382843 hasConcept C54355233 @default.
- W2088382843 hasConcept C86803240 @default.
- W2088382843 hasConcept C956191 @default.
- W2088382843 hasConceptScore W2088382843C121608353 @default.
- W2088382843 hasConceptScore W2088382843C153911025 @default.
- W2088382843 hasConceptScore W2088382843C159654299 @default.
- W2088382843 hasConceptScore W2088382843C167734588 @default.
- W2088382843 hasConceptScore W2088382843C186268636 @default.
- W2088382843 hasConceptScore W2088382843C203014093 @default.
- W2088382843 hasConceptScore W2088382843C204232928 @default.
- W2088382843 hasConceptScore W2088382843C2777025900 @default.
- W2088382843 hasConceptScore W2088382843C2778690821 @default.
- W2088382843 hasConceptScore W2088382843C2780394083 @default.
- W2088382843 hasConceptScore W2088382843C2780659158 @default.
- W2088382843 hasConceptScore W2088382843C2781018059 @default.
- W2088382843 hasConceptScore W2088382843C29537977 @default.
- W2088382843 hasConceptScore W2088382843C502942594 @default.
- W2088382843 hasConceptScore W2088382843C54355233 @default.
- W2088382843 hasConceptScore W2088382843C86803240 @default.
- W2088382843 hasConceptScore W2088382843C956191 @default.
- W2088382843 hasLocation W20883828431 @default.
- W2088382843 hasLocation W20883828432 @default.
- W2088382843 hasOpenAccess W2088382843 @default.
- W2088382843 hasPrimaryLocation W20883828431 @default.
- W2088382843 hasRelatedWork W111063158 @default.
- W2088382843 hasRelatedWork W125583516 @default.
- W2088382843 hasRelatedWork W146810371 @default.
- W2088382843 hasRelatedWork W147398146 @default.
- W2088382843 hasRelatedWork W1847566570 @default.
- W2088382843 hasRelatedWork W185479028 @default.
- W2088382843 hasRelatedWork W185938529 @default.
- W2088382843 hasRelatedWork W2034973828 @default.
- W2088382843 hasRelatedWork W206701898 @default.
- W2088382843 hasRelatedWork W211284186 @default.
- W2088382843 hasRelatedWork W21149459 @default.
- W2088382843 hasRelatedWork W27919971 @default.
- W2088382843 hasRelatedWork W60759546 @default.
- W2088382843 hasRelatedWork W74992319 @default.
- W2088382843 hasRelatedWork W78060682 @default.
- W2088382843 hasRelatedWork W127950164 @default.
- W2088382843 hasRelatedWork W154116810 @default.
- W2088382843 hasRelatedWork W187819402 @default.
- W2088382843 hasRelatedWork W91598526 @default.
- W2088382843 hasRelatedWork W98091425 @default.
- W2088382843 isParatext "false" @default.
- W2088382843 isRetracted "false" @default.
- W2088382843 magId "2088382843" @default.
- W2088382843 workType "article" @default.