FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088385191> ?p ?o ?g. }

• W2088385191 endingPage "1559" @default.
• W2088385191 startingPage "1550" @default.
• W2088385191 abstract "Bcl-2 is a gene family involved in the suppression of apoptosis in response to a wide range of cellular insults. Multiple papers have suggested a link between Bcl-2 and oxidative damage/antioxidant protection. We therefore examined parameters of antioxidant defense and oxidative damage in two different cell lines, NT-2/D1 (NT-2) and SK-N-MC, overexpressing Bcl-2 as compared with vector-only controls. Bcl-2 transfectants of both cell lines were more resistant to H(2)O(2) and showed increases in GSH level and Cu/Zn-superoxide dismutase (SOD1) activity, but not in Mn-superoxide dismutase, glutathione peroxidase, or glutathione reductase activities. Catalase activity was increased in SK-N-MC cells. Overexpression of Bcl-2 did not significantly decrease levels of oxidative DNA damage (measured as 8-hydroxyguanine) or lipid peroxidation, but it decreased levels of 3-nitrotyrosine in both cell lines and protein carbonyls in SK-N-MC cells only. It also increased proteasome activity in both cell lines. We conclude that Bcl-2 raises cellular antioxidant defense status, but this is not necessarily reflected in decreased levels of oxidative damage to DNA and lipids. The ability of Bcl-2 overexpression to decrease 3-nitrotyrosine levels suggests that it may decrease formation of peroxynitrite or other reactive nitrogen species; this was confirmed as decreased production of NO(2)(-)/NO(3)(-) in the transfected cells and a fall in the level of nNOS protein." @default.
• W2088385191 created "2016-06-24" @default.
• W2088385191 creator A5005404981 @default.
• W2088385191 creator A5025894712 @default.
• W2088385191 creator A5030909442 @default.
• W2088385191 creator A5043919479 @default.
• W2088385191 creator A5046805605 @default.
• W2088385191 creator A5053726981 @default.
• W2088385191 creator A5071827538 @default.
• W2088385191 date "2001-12-15" @default.
• W2088385191 modified "2023-09-30" @default.
• W2088385191 title "Effect of overexpression of Bcl-2 on cellular oxidative damage, nitric oxide production, antioxidant defenses, and the proteasome" @default.
• W2088385191 cites W1531318383 @default.
• W2088385191 cites W1544396026 @default.
• W2088385191 cites W1546592314 @default.
• W2088385191 cites W1549250991 @default.
• W2088385191 cites W1588232325 @default.
• W2088385191 cites W1718709781 @default.
• W2088385191 cites W1775749144 @default.
• W2088385191 cites W1801632833 @default.
• W2088385191 cites W1888117364 @default.
• W2088385191 cites W1901643819 @default.
• W2088385191 cites W1940436875 @default.
• W2088385191 cites W1967454025 @default.
• W2088385191 cites W1969334497 @default.
• W2088385191 cites W1974185399 @default.
• W2088385191 cites W1997208169 @default.
• W2088385191 cites W2002806269 @default.
• W2088385191 cites W2005663073 @default.
• W2088385191 cites W2008861924 @default.
• W2088385191 cites W2009041565 @default.
• W2088385191 cites W2011272696 @default.
• W2088385191 cites W2021544813 @default.
• W2088385191 cites W2026261400 @default.
• W2088385191 cites W2037473273 @default.
• W2088385191 cites W2038768123 @default.
• W2088385191 cites W2042254126 @default.
• W2088385191 cites W2049983049 @default.
• W2088385191 cites W2051795235 @default.
• W2088385191 cites W2051958084 @default.
• W2088385191 cites W2053640261 @default.
• W2088385191 cites W2063568808 @default.
• W2088385191 cites W2071850731 @default.
• W2088385191 cites W2074359673 @default.
• W2088385191 cites W2076883436 @default.
• W2088385191 cites W2078741049 @default.
• W2088385191 cites W2079822311 @default.
• W2088385191 cites W2080391833 @default.
• W2088385191 cites W2082294005 @default.
• W2088385191 cites W2090099409 @default.
• W2088385191 cites W2113999599 @default.
• W2088385191 cites W2114443210 @default.
• W2088385191 cites W2126608948 @default.
• W2088385191 cites W2129912243 @default.
• W2088385191 cites W2135725455 @default.
• W2088385191 cites W2137832426 @default.
• W2088385191 cites W2152719751 @default.
• W2088385191 cites W2152884976 @default.
• W2088385191 cites W2153667576 @default.
• W2088385191 cites W2155854925 @default.
• W2088385191 cites W2163943333 @default.
• W2088385191 cites W2164066515 @default.
• W2088385191 cites W2236976158 @default.
• W2088385191 cites W2396567129 @default.
• W2088385191 cites W28016325 @default.
• W2088385191 cites W2153943744 @default.
• W2088385191 doi "https://doi.org/10.1016/s0891-5849(01)00633-5" @default.
• W2088385191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11744329" @default.
• W2088385191 hasPublicationYear "2001" @default.
• W2088385191 type Work @default.
• W2088385191 sameAs 2088385191 @default.
• W2088385191 citedByCount "105" @default.
• W2088385191 countsByYear W20883851912012 @default.
• W2088385191 countsByYear W20883851912013 @default.
• W2088385191 countsByYear W20883851912014 @default.
• W2088385191 countsByYear W20883851912015 @default.
• W2088385191 countsByYear W20883851912016 @default.
• W2088385191 countsByYear W20883851912017 @default.
• W2088385191 countsByYear W20883851912018 @default.
• W2088385191 countsByYear W20883851912020 @default.
• W2088385191 countsByYear W20883851912021 @default.
• W2088385191 countsByYear W20883851912023 @default.
• W2088385191 crossrefType "journal-article" @default.
• W2088385191 hasAuthorship W2088385191A5005404981 @default.
• W2088385191 hasAuthorship W2088385191A5025894712 @default.
• W2088385191 hasAuthorship W2088385191A5030909442 @default.
• W2088385191 hasAuthorship W2088385191A5043919479 @default.
• W2088385191 hasAuthorship W2088385191A5046805605 @default.
• W2088385191 hasAuthorship W2088385191A5053726981 @default.
• W2088385191 hasAuthorship W2088385191A5071827538 @default.
• W2088385191 hasConcept C143425029 @default.
• W2088385191 hasConcept C153911025 @default.
• W2088385191 hasConcept C165069038 @default.
• W2088385191 hasConcept C178790620 @default.
• W2088385191 hasConcept C181199279 @default.
• W2088385191 hasConcept C185592680 @default.
• W2088385191 hasConcept C2775838275 @default.
• W2088385191 hasConcept C2776151105 @default.

• next