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• W2088390543 endingPage "2907" @default.
• W2088390543 startingPage "2901" @default.
• W2088390543 abstract "Preterm infants are at risk of developing germinal matrix hemorrhages-intraventricular hemorrhages (GMH-IVH). Disturbances in cerebral perfusion are associated with GMH-IVH. Regional cerebral tissue oxygen saturation (r(c)SO₂), measured with near-infrared spectroscopy, and fractional tissue oxygen extraction (FTOE) were calculated to obtain an indication of cerebral perfusion. Our objective was to determine whether r(c)SO₂ and FTOE were associated with GMH-IVH in preterm infants.This case-control study included 17 preterm infants with Grade I to III GMH-IVH or periventricular hemorrhagic infarction (median gestational age, 29.4 weeks; range, 25.4 to 31.9 weeks; birth weight, 1260 g; range, 850 to 1840 g). Seventeen preterm infants without GMH-IVH, matched for gestational age and birth weight, served as control subjects (gestational age, 29.9 weeks; range, 26.0 to 31.6 weeks; birth weight, 1310 g; range, 730 to 1975 g). R(c)SO₂ and transcutaneous arterial oxygen saturation were measured during 2 hours on Days 1 to 5, 8, and 15 after birth. FTOE was calculated as FTOE=(transcutaneous arterial oxygen saturation-r(c)SO₂)/transcutaneous arterial oxygen saturation.Multilevel analyses showed that r(c)SO₂ was lower and FTOE higher in infants with GMH-IVH on Days 1, 2, 3, 4, 5, 8, and 15. The largest difference occurred on Day 5 with r(c)SO₂ median 64% in infants with GMH-IVH versus 77% in control subjects and FTOE median 0.30 versus 0.17. R(c)SO₂ and FTOE were not affected by the grade of GMH-IVH.Preterm infants with GMH-IVH had lower r(c)SO₂ and higher FTOE during the first 2 weeks after birth irrespective of the grade of GMH-IVH. This suggests that cerebral perfusion is decreased persistently for 2 weeks in infants with GMH-IVH, even in the presence of mild hemorrhages." @default.
• W2088390543 created "2016-06-24" @default.
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• W2088390543 date "2010-12-01" @default.
• W2088390543 modified "2023-09-27" @default.
• W2088390543 title "Cerebral Oxygenation in Preterm Infants With Germinal Matrix–Intraventricular Hemorrhages" @default.
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• W2088390543 doi "https://doi.org/10.1161/strokeaha.110.597229" @default.
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• W2088390543 hasPublicationYear "2010" @default.
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