FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088390812> ?p ?o ?g. }

• W2088390812 endingPage "760" @default.
• W2088390812 startingPage "747" @default.
• W2088390812 abstract "Losartan potassium was the first in a new class of potent angiotensin II receptor antagonists which are well-tolerated in the treatment of hypertension. Losartan potassium is the active ingredient in tablets COZAAR and is combined with diuretic co-active hydrochlorothiazide (HCTZ) in tablets HYZAAR for increased efficacy. Losartan potassium has one main impurity and two primary degradates. HCTZ has one major degradate as well as two common process impurities. Historically, separate methods have been used for the analysis of each active and their respective impurities and degradates. The ultimate goal of this work was to develop and validate a single high-performance liquid chromatography method selective for the eight main components of tablets HYZAAR. A single method was developed to afford simultaneous quantitation of actives and degradates for each of the two existing formulations. Each method is presented herein and demonstrated to be suitable for quantitation to 0.1% levels of all relevant degradates, as well as 100% levels of respective drug substances." @default.
• W2088390812 created "2016-06-24" @default.
• W2088390812 creator A5000747790 @default.
• W2088390812 creator A5043687506 @default.
• W2088390812 creator A5081665956 @default.
• W2088390812 creator A5083591096 @default.
• W2088390812 creator A5086938999 @default.
• W2088390812 date "2002-10-01" @default.
• W2088390812 modified "2023-09-26" @default.
• W2088390812 title "Development and validation of a stability-indicating HPLC method for the simultaneous determination of Losartan potassium, hydrochlorothiazide, and their degradation products" @default.
• W2088390812 cites W1965713047 @default.
• W2088390812 cites W1968377879 @default.
• W2088390812 cites W1971861764 @default.
• W2088390812 cites W1990031109 @default.
• W2088390812 cites W2005048715 @default.
• W2088390812 cites W2010671887 @default.
• W2088390812 cites W2014649829 @default.
• W2088390812 cites W2024649627 @default.
• W2088390812 cites W2046736212 @default.
• W2088390812 cites W2047232086 @default.
• W2088390812 cites W2081882891 @default.
• W2088390812 cites W2086760877 @default.
• W2088390812 cites W2091282214 @default.
• W2088390812 cites W2097712021 @default.
• W2088390812 cites W2103731897 @default.
• W2088390812 cites W2147152119 @default.
• W2088390812 cites W2158473455 @default.
• W2088390812 cites W2227086300 @default.
• W2088390812 cites W2324708269 @default.
• W2088390812 cites W4231220755 @default.
• W2088390812 doi "https://doi.org/10.1016/s0731-7085(02)00385-0" @default.
• W2088390812 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12367701" @default.
• W2088390812 hasPublicationYear "2002" @default.
• W2088390812 type Work @default.
• W2088390812 sameAs 2088390812 @default.
• W2088390812 citedByCount "108" @default.
• W2088390812 countsByYear W20883908122012 @default.
• W2088390812 countsByYear W20883908122013 @default.
• W2088390812 countsByYear W20883908122014 @default.
• W2088390812 countsByYear W20883908122015 @default.
• W2088390812 countsByYear W20883908122016 @default.
• W2088390812 countsByYear W20883908122017 @default.
• W2088390812 countsByYear W20883908122018 @default.
• W2088390812 countsByYear W20883908122019 @default.
• W2088390812 countsByYear W20883908122020 @default.
• W2088390812 countsByYear W20883908122021 @default.
• W2088390812 countsByYear W20883908122022 @default.
• W2088390812 countsByYear W20883908122023 @default.
• W2088390812 crossrefType "journal-article" @default.
• W2088390812 hasAuthorship W2088390812A5000747790 @default.
• W2088390812 hasAuthorship W2088390812A5043687506 @default.
• W2088390812 hasAuthorship W2088390812A5081665956 @default.
• W2088390812 hasAuthorship W2088390812A5083591096 @default.
• W2088390812 hasAuthorship W2088390812A5086938999 @default.
• W2088390812 hasConcept C126322002 @default.
• W2088390812 hasConcept C170493617 @default.
• W2088390812 hasConcept C178790620 @default.
• W2088390812 hasConcept C179998833 @default.
• W2088390812 hasConcept C185592680 @default.
• W2088390812 hasConcept C2779918671 @default.
• W2088390812 hasConcept C2780288358 @default.
• W2088390812 hasConcept C2780361556 @default.
• W2088390812 hasConcept C2908929049 @default.
• W2088390812 hasConcept C2909209853 @default.
• W2088390812 hasConcept C43617362 @default.
• W2088390812 hasConcept C45904493 @default.
• W2088390812 hasConcept C517785266 @default.
• W2088390812 hasConcept C55493867 @default.
• W2088390812 hasConcept C71924100 @default.
• W2088390812 hasConcept C71987851 @default.
• W2088390812 hasConcept C84393581 @default.
• W2088390812 hasConcept C98274493 @default.
• W2088390812 hasConceptScore W2088390812C126322002 @default.
• W2088390812 hasConceptScore W2088390812C170493617 @default.
• W2088390812 hasConceptScore W2088390812C178790620 @default.
• W2088390812 hasConceptScore W2088390812C179998833 @default.
• W2088390812 hasConceptScore W2088390812C185592680 @default.
• W2088390812 hasConceptScore W2088390812C2779918671 @default.
• W2088390812 hasConceptScore W2088390812C2780288358 @default.
• W2088390812 hasConceptScore W2088390812C2780361556 @default.
• W2088390812 hasConceptScore W2088390812C2908929049 @default.
• W2088390812 hasConceptScore W2088390812C2909209853 @default.
• W2088390812 hasConceptScore W2088390812C43617362 @default.
• W2088390812 hasConceptScore W2088390812C45904493 @default.
• W2088390812 hasConceptScore W2088390812C517785266 @default.
• W2088390812 hasConceptScore W2088390812C55493867 @default.
• W2088390812 hasConceptScore W2088390812C71924100 @default.
• W2088390812 hasConceptScore W2088390812C71987851 @default.
• W2088390812 hasConceptScore W2088390812C84393581 @default.
• W2088390812 hasConceptScore W2088390812C98274493 @default.
• W2088390812 hasIssue "3" @default.
• W2088390812 hasLocation W20883908121 @default.
• W2088390812 hasLocation W20883908122 @default.
• W2088390812 hasOpenAccess W2088390812 @default.
• W2088390812 hasPrimaryLocation W20883908121 @default.
• W2088390812 hasRelatedWork W1965482421 @default.
• W2088390812 hasRelatedWork W1971607801 @default.
• W2088390812 hasRelatedWork W2077347655 @default.

• next