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- W2088391281 abstract "To investigate the BioPlex 2200 multiplex immunoassay and Farrzyme ELISA assays as alternatives to the established Farr radioimmunoassay for the correlation of anti-dsDNA antibodies in the assessment of disease activity in systemic lupus erythematosus (SLE). Standard protocols were used to verify analytical performance claims. Anti-dsDNA antibody levels in SLE patient specimens (N = 105) were measured and assessed for clinical performance using manufacturer cut-off limits along with the Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) score. Assay precision, measurable range and normal reference interval met the manufacturers' stated claims. Agreement between Farr and BioPlex assays was moderate (positive agreement = 62%; negative agreement = 85%; kappa = 0.48), as was agreement between Farr and Farrzyme assays (positive agreement = 56%; negative agreement = 91%; kappa = 0.51). Mean SLEDAI-2K scores differed significantly between the anti-dsDNA positive and negative groups for BioPlex (p = 0.0006), but not Farr (p = 0.11) or Farrzyme (p = 0.34). ROC curve analysis showed a similar area under the curve (AUC) for all three assays (0.76, 0.74, and 0.73 for Farr, BioPlex, and Farrzyme, respectively) in the discrimination of clinically active disease. Furthermore, increased anti-dsDNA levels from BioPlex showed significant correlation with active renal disease. However, results suggested a lower cut-off for the Farrzyme assay for assessment of global disease activity. BioPlex and Farrzyme assays had similar overall agreement with the Farr assay, with BioPlex best reflecting disease activity in SLE patients." @default.
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- W2088391281 date "2013-03-01" @default.
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- W2088391281 title "Comparison of three anti-dsDNA assays: Performance and correlation with systemic lupus erythematosus disease activity" @default.
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- W2088391281 doi "https://doi.org/10.1016/j.clinbiochem.2012.12.004" @default.
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