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- W2088391411 abstract "Female ddY mice were administered 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) by gavage for 8 weeks prior to pregnancy. In the male breast-fed offspring born to the TCDD-exposed mice, serotonergic neurons in the brainstem were examined using an immunocytochemical method at 42 days of age. In all offspring, a marked decrease in the intensity of immunostaining occurred in all raphe nuclei compared with the control offspring. The number of serotonin-immunoreactive neurons in each raphe nucleus was measured by computer-assisted analysis. Approximately a quarter to half of immunoreactive neurons were detected in the TCDD-exposed offspring raphe nuclei compared with the control offspring. The present findings suggest that in utero and/or lactational TCDD exposure cause a long-lasting change in the serotonergic system in the raphe nuclei of offspring." @default.
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- W2088391411 date "2002-01-01" @default.
- W2088391411 modified "2023-10-14" @default.
- W2088391411 title "In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo- p -dioxin decreases serotonin-immunoreactive neurons in raphe nuclei of male mouse offspring" @default.
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- W2088391411 doi "https://doi.org/10.1016/s0304-3940(01)02434-x" @default.
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