FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088392077> ?p ?o ?g. }

• W2088392077 endingPage "324" @default.
• W2088392077 startingPage "317" @default.
• W2088392077 abstract "This report characterizes the P450 isoenzymes involved in quinine metabolism in liver microsomes of the common brush-tailed possum (Trichosurus vulpecula). The mean maximal velocity (V max ) for 3-hydroxyquinine formation in possum livers was 1,512 ± 510 pmol/mg protein/min (males) and 1,680 ± 690 pmol/mg protein/min (females). The mean V max value for 3-hydroxyquinine formation in possums was approximately threefold higher than that found in human livers. The mean apparent Michaelis constant (K m ) for 3-hydroxyquinine formation in possum livers was 31.9 ± 16 μM in males and 16.1 ± 5 μM in females. At low concentrations of quinine (40 μM), the quinine 3-hydroxylation was inhibited more than 90% by midazolam, 60% by troleandomycin, 40% by erythromycin, and 47% by nifedipine, all of which are CYP3A inhibitors. Other inhibitors for CYP2C9/ 10, CYP2D6, CYP2E1, and CYP1A1/2 showed little or no inhibition effect on 3-hydroxylation of quinine. Xenobiotic inhibition studies suggest that the liver CYP3A enzyme family or one similar to human liver CYP3A is responsible for 3-hydroxylation of quinine in possum livers. The metabolism of midazolam to 1'-hydroxy and 4-hydroxy metabolites was also studied. The in vitro metabolism of midazolam was found to be much lower in possum liver microsomes as compared to that observed in human liver microsomes. The mean V max values for 4-hydroxy- and 1'-hydroxymidazolam in male possums were 179 ± 53 and 479 ± 333 pmol/mg protein/min, respectively. For female possums, the mean V max values were 235 ± 31 and 671 ± 143 pmol/mg protein/ min, respectively. These V max values for male possums were 23 and 8 times less (17 and 6 times less for female possums), respectively, than those observed with human liver microsomes. The present study has demonstrated that, although possums are able to metabolize both midazolam and quinine, the capacity to metabolize midazolam is considerably lower in possum livers than in human livers. This finding could be useful for the selection of alternative poisons to control populations of possums." @default.
• W2088392077 created "2016-06-24" @default.
• W2088392077 creator A5007295759 @default.
• W2088392077 creator A5007728080 @default.
• W2088392077 creator A5027660305 @default.
• W2088392077 creator A5047513962 @default.
• W2088392077 creator A5073479378 @default.
• W2088392077 date "1998-02-01" @default.
• W2088392077 modified "2023-09-26" @default.
• W2088392077 title "In vitro hepatic metabolism of CYP3A-mediated drugs quinine and midazolam in the common brush-tailed possum (Trichosurus vulpecula)" @default.
• W2088392077 cites W1540726821 @default.
• W2088392077 cites W161985329 @default.
• W2088392077 cites W1821066907 @default.
• W2088392077 cites W1971236082 @default.
• W2088392077 cites W1974860935 @default.
• W2088392077 cites W1978470492 @default.
• W2088392077 cites W1987496326 @default.
• W2088392077 cites W1993780682 @default.
• W2088392077 cites W2003754121 @default.
• W2088392077 cites W2004352353 @default.
• W2088392077 cites W2025433517 @default.
• W2088392077 cites W2030595001 @default.
• W2088392077 cites W2037812043 @default.
• W2088392077 cites W2040926460 @default.
• W2088392077 cites W2050270637 @default.
• W2088392077 cites W2059293500 @default.
• W2088392077 cites W2061539226 @default.
• W2088392077 cites W2067525361 @default.
• W2088392077 cites W2078137445 @default.
• W2088392077 cites W2093529618 @default.
• W2088392077 cites W2105681476 @default.
• W2088392077 cites W2122856423 @default.
• W2088392077 cites W2335881284 @default.
• W2088392077 doi "https://doi.org/10.1002/etc.5620170224" @default.
• W2088392077 hasPublicationYear "1998" @default.
• W2088392077 type Work @default.
• W2088392077 sameAs 2088392077 @default.
• W2088392077 citedByCount "1" @default.
• W2088392077 crossrefType "journal-article" @default.
• W2088392077 hasAuthorship W2088392077A5007295759 @default.
• W2088392077 hasAuthorship W2088392077A5007728080 @default.
• W2088392077 hasAuthorship W2088392077A5027660305 @default.
• W2088392077 hasAuthorship W2088392077A5047513962 @default.
• W2088392077 hasAuthorship W2088392077A5073479378 @default.
• W2088392077 hasConcept C109650736 @default.
• W2088392077 hasConcept C11824378 @default.
• W2088392077 hasConcept C126322002 @default.
• W2088392077 hasConcept C134018914 @default.
• W2088392077 hasConcept C181199279 @default.
• W2088392077 hasConcept C202751555 @default.
• W2088392077 hasConcept C203014093 @default.
• W2088392077 hasConcept C2776814716 @default.
• W2088392077 hasConcept C2777477808 @default.
• W2088392077 hasConcept C2777617192 @default.
• W2088392077 hasConcept C2778000748 @default.
• W2088392077 hasConcept C2778048844 @default.
• W2088392077 hasConcept C2781109383 @default.
• W2088392077 hasConcept C526171541 @default.
• W2088392077 hasConcept C55493867 @default.
• W2088392077 hasConcept C62231903 @default.
• W2088392077 hasConcept C71924100 @default.
• W2088392077 hasConcept C86803240 @default.
• W2088392077 hasConcept C87644729 @default.
• W2088392077 hasConcept C89311334 @default.
• W2088392077 hasConcept C98274493 @default.
• W2088392077 hasConceptScore W2088392077C109650736 @default.
• W2088392077 hasConceptScore W2088392077C11824378 @default.
• W2088392077 hasConceptScore W2088392077C126322002 @default.
• W2088392077 hasConceptScore W2088392077C134018914 @default.
• W2088392077 hasConceptScore W2088392077C181199279 @default.
• W2088392077 hasConceptScore W2088392077C202751555 @default.
• W2088392077 hasConceptScore W2088392077C203014093 @default.
• W2088392077 hasConceptScore W2088392077C2776814716 @default.
• W2088392077 hasConceptScore W2088392077C2777477808 @default.
• W2088392077 hasConceptScore W2088392077C2777617192 @default.
• W2088392077 hasConceptScore W2088392077C2778000748 @default.
• W2088392077 hasConceptScore W2088392077C2778048844 @default.
• W2088392077 hasConceptScore W2088392077C2781109383 @default.
• W2088392077 hasConceptScore W2088392077C526171541 @default.
• W2088392077 hasConceptScore W2088392077C55493867 @default.
• W2088392077 hasConceptScore W2088392077C62231903 @default.
• W2088392077 hasConceptScore W2088392077C71924100 @default.
• W2088392077 hasConceptScore W2088392077C86803240 @default.
• W2088392077 hasConceptScore W2088392077C87644729 @default.
• W2088392077 hasConceptScore W2088392077C89311334 @default.
• W2088392077 hasConceptScore W2088392077C98274493 @default.
• W2088392077 hasIssue "2" @default.
• W2088392077 hasLocation W20883920771 @default.
• W2088392077 hasOpenAccess W2088392077 @default.
• W2088392077 hasPrimaryLocation W20883920771 @default.
• W2088392077 hasRelatedWork W1967274635 @default.
• W2088392077 hasRelatedWork W2029949604 @default.
• W2088392077 hasRelatedWork W2044453286 @default.
• W2088392077 hasRelatedWork W2045494870 @default.
• W2088392077 hasRelatedWork W2075120138 @default.
• W2088392077 hasRelatedWork W2088392077 @default.
• W2088392077 hasRelatedWork W2092063638 @default.
• W2088392077 hasRelatedWork W2131532005 @default.

• next