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• W2088392365 abstract "MicroRNAs (miRNAs) play key roles in cancer development and progression. In the present study, we investigated the role of miR-340 in the progression and metastasis of osteosarcoma (OS). Our results showed that miR-340 was frequently downregulated in OS tumors and cell lines. Overexpression of miR-340 in OS cell lines significantly inhibited cell proliferation, migration, and invasion in vitro, and tumor growth and metastasis in a xenograft mouse model. ROCK1 was identified as a target of miR-340, and ectopic expression of miR-340 downregulated ROCK1 by direct binding to its 3' untranslated region. siRNA-mediated silencing of ROCK1 phenocopied the effects of miR-340 overexpression, whereas restoration of ROCK1 in miR-340-overexpressing OS cells reversed the suppressive effects of miR-340. Together, these findings indicate that miR-340 acts as a tumor suppressor and its downregulation in tumor tissues may contribute to the progression and metastasis of OS through a mechanism involving ROCK1, suggesting miR-340 as a potential new diagnostic and therapeutic target for the treatment of OS." @default.
• W2088392365 created "2016-06-24" @default.
• W2088392365 creator A5033435917 @default.
• W2088392365 creator A5046597133 @default.
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• W2088392365 date "2013-08-01" @default.
• W2088392365 modified "2023-10-03" @default.
• W2088392365 title "MicroRNA-340 suppresses osteosarcoma tumor growth and metastasis by directly targeting ROCK1" @default.
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• W2088392365 doi "https://doi.org/10.1016/j.bbrc.2013.07.033" @default.
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