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• W2088392385 endingPage "88" @default.
• W2088392385 startingPage "75" @default.
• W2088392385 abstract "Exposure to either ionizing radiation or certain transition metals results in generation of reactive oxygen species that induce DNA damage, mutation, and cancer. Vitamin C (a reactive oxygen scavenger) is considered to be a dietary radioprotective agent. However, it has been reported to be genotoxic in the presence of certain transition metals, including copper. In order to explore the capacity of vitamin C to protect DNA from radiation-induced damage, and the influence of the presence of copper on this protection, we investigated vitamin C-mediated protection against radiation-induced damage to calf thymus DNA in vitro in the presence or absence of copper(II). Vitamin C (0.08-8.00 mM, pH 7.0) significantly reduced DNA damage induced by gamma-irradiation (30-150 Gy) by 30-50%, similar to the protective effect of glutathione. However, vitamin C plus copper (50 microM) significantly enhanced gamma-radiation-induced DNA damage. Low levels of added copper (5 microM), or chelation of copper with 1-N-benzyltriethylenetetraine tetrahydrochloride (BzTrien) and bathocuprinedisulfonic acid (BCSA), abolished the enhanced damage without diminishing the protective effect of vitamin C. These results indicate that vitamin C can act as: (1) an antioxidant to protect DNA damage from ionizing radiation; and (2) a reducing agent in the presence of copper to induce DNA damage. These effects are important in assessing the role of vitamin C, in the presence of mineral supplements or radioprotective therapeutic agents, particularly in patients with abnormally high tissue copper levels." @default.
• W2088392385 created "2016-06-24" @default.
• W2088392385 creator A5008902550 @default.
• W2088392385 creator A5017873319 @default.
• W2088392385 creator A5045654062 @default.
• W2088392385 date "2001-07-01" @default.
• W2088392385 modified "2023-10-17" @default.
• W2088392385 title "Roles of vitamin C in radiation-induced DNA damage in presence and absence of copper" @default.
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• W2088392385 doi "https://doi.org/10.1016/s0009-2797(01)00210-1" @default.
• W2088392385 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11518565" @default.
• W2088392385 hasPublicationYear "2001" @default.
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