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• W2088393400 endingPage "132" @default.
• W2088393400 startingPage "125" @default.
• W2088393400 abstract "Human serum albumin (HSA) nanoparticles (NP) were prepared by desolvation. Insulin or an anti-insulin receptor monoclonal antibody (29B4) were covalently coupled to the HSA NP, using the NHS-PEG-MAL-5000 crosslinker. Loperamide-loaded HSA NP with covalently bound insulin or the 29B4 antibodies induced significant antinociceptive effects in the tail-flick test in ICR (CD-1) mice after intravenous injection, demonstrating that insulin or these antibodies covalently coupled to HSA NP are able to transport loperamide across the blood–brain barrier (BBB) which it normally is unable to cross. Control loperamide-loaded HSA NP with immunoglobulin G antibodies yielded only marginal effects. The loperamide transport across the BBB using the NP with covalently attached insulin could be totally inhibited by the pretreatment with the antibody 29B4." @default.
• W2088393400 created "2016-06-24" @default.
• W2088393400 creator A5012685771 @default.
• W2088393400 creator A5056026128 @default.
• W2088393400 creator A5059960847 @default.
• W2088393400 date "2010-04-13" @default.
• W2088393400 modified "2023-10-18" @default.
• W2088393400 title "Targeting the insulin receptor: nanoparticles for drug delivery across the blood–brain barrier (BBB)" @default.
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• W2088393400 doi "https://doi.org/10.3109/10611861003734001" @default.
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• W2088393400 hasPublicationYear "2010" @default.
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