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• W2088394529 abstract "Autophagy is a self-digestion process in which intracellular structures are degraded in response to stress. Notably, prolonged autophagy leads to cell death. In this study, we investigated whether CX-4945, an orally available protein kinase 2 (CK2) inhibitor, induces autophagic cell death in human cervical cancer-derived HeLa cells and in human prostate cancer-derived LNCaP cells. CX-4945 treatment of both cell lines resulted in the formation of autophagosomes, in the conversion of microtubule-associated protein 1 light chain 3 (LC3), and in down-regulation of the Akt-mammalian target of rapamycin (mTOR)-p70 ribosomal protein S6 kinase (S6K) signaling cascade. Thus, pharmacologic inhibition of CK2 by CX-4945 induced autophagic cell death in human cancer cells by down-regulating Akt-mTOR-S6K. These results suggest that autophagy-inducing agents have potential as anti-cancer drugs." @default.
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• W2088394529 date "2014-10-20" @default.
• W2088394529 modified "2023-09-24" @default.
• W2088394529 title "The Protein Kinase 2 Inhibitor CX-4945 Induces Autophagy in Human Cancer Cell Lines" @default.
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• W2088394529 doi "https://doi.org/10.5012/bkcs.2014.35.10.2985" @default.
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