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• W2088395466 endingPage "222" @default.
• W2088395466 startingPage "213" @default.
• W2088395466 abstract "Profound neuropeptide diversity characterizes the nematode nervous system, but it has proven challenging to match neuropeptide G protein-coupled receptors (GPCR) with their cognate ligands in heterologous systems. We have expressed the Caenorhabditis elegans GPCR encoded in the locus T19F4.1, previously matched with FMRFamide-like peptides encoded on the flp-2 precursor gene, in mammalian cells and in the yeast Saccharomyces cerevisiae. Pharmacological characterization revealed that the receptor is potently activated by flp-2 peptides in CHO cells (∼10 nM EC50) and in yeast (∼100 nM EC50), signaling through a Gqα pathway in each system. The yeast GPCR expression system provides a robust assay for screening for agonists of the flp-2 receptor and is the target of an ongoing high-throughput screening exercise." @default.
• W2088395466 created "2016-06-24" @default.
• W2088395466 creator A5031692281 @default.
• W2088395466 date "1992-06-01" @default.
• W2088395466 modified "2023-10-13" @default.
• W2088395466 title "Neuroactive peptides with an RFamide or Famide carboxyl terminal" @default.
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• W2088395466 doi "https://doi.org/10.1016/0742-8413(92)90104-f" @default.
• W2088395466 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1358534" @default.
• W2088395466 hasPublicationYear "1992" @default.

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