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- W2088395718 abstract "GPR35 is an orphan G protein-coupled receptor that is not well-characterized. Here we employ dynamic mass redistribution (DMR) assays to discover new GPR35 agonists. DMR assays identified tyrphostin analogs as GPR35 agonists, which were confirmed with receptor internalization, Tango β-arrestin translocation, and extracellular-signal-regulated kinase phosphorylation assays. These agonists provide pharmacological tools to study the biology and function of GPR35." @default.
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- W2088395718 date "2011-05-17" @default.
- W2088395718 modified "2023-10-12" @default.
- W2088395718 title "Tyrphostin analogs are GPR35 agonists" @default.
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- W2088395718 doi "https://doi.org/10.1016/j.febslet.2011.05.026" @default.
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