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• W2088396557 abstract "The differentiation-inducing factor-1 (DIF-1) is a lipophilic signal molecule (chlorinated alkylphenone) that induces stalk cell differentiation in the cellular slime mold Dictyostelium discoideum. In addition, DIF-1 and its derivatives have been shown to possess anti-leukemic activity and glucose consumption-promoting activity in vitro in mammalian cells. In this study, to assess the chemical structure–effect relationship of DIF-1, we synthesized eight derivatives of DIF-1 and investigated their stalk cell-inducing activity in Dictyostelium cells and pharmacological activities in mammalian cells. Of the derivatives, two amide derivatives of DIF-1, whose hydrophobic indexes are close to that of DIF-1, induced stalk cell differentiation as strongly as DIF-1 in Dictyostelium cells. It was also found that some derivatives suppressed cell growth in human K562 leukemia cells and promoted glucose consumption in mouse 3T3-L1 cells. These results give us valuable information as to the chemical structure–effect relationship of DIF-1." @default.
• W2088396557 created "2016-06-24" @default.
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• W2088396557 date "2008-12-01" @default.
• W2088396557 modified "2023-09-27" @default.
• W2088396557 title "Biological activities of novel derivatives of DIF-1 isolated from Dictyostelium" @default.
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• W2088396557 doi "https://doi.org/10.1016/j.bbrc.2008.10.105" @default.
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