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• W2088397835 abstract "No AccessJournal of UrologyInvestigative Urology1 Feb 1997Prostatic Intraepithelial Neoplasia Occurs Spontaneously in the Canine Prostate David J. Waters and David G. Bostwick David J. WatersDavid J. Waters More articles by this author and David G. BostwickDavid G. Bostwick More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)65256-XAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Prostatic intraepithelial neoplasia (PIN) is the most likely precursor of human prostate cancer. Although the dog is the only non-human species in which spontaneous prostate cancer occurs frequently, the prevalence of PIN in the canine prostate is unknown. A naturally occurring animal model of PIN has not been described. Materials and Methods: To determine if high grade PIN occurs spontaneously in the canine prostate, we evaluated totally embedded prostates from 35 outbred dogs that had no clinical evidence of prostatic disease. Prostates from three groups of dogs were analyzed: (1) 11 sexually intact dogs 7-17 years old (elderly sexually intact); (2) 13 sexually intact dogs 1-4 years old (young sexually intact); and (3) 11 dogs 7-17 years old that had been castrated (elderly castrated). The prevalence of PIN was determined by systematic evaluation of hematoxylin/eosin and high molecular weight keratin 34 beta-E12 stained tissue sections from formalin-fixed, paraffin embedded prostates that had been serially sectioned at 4 mm intervals. Results: Canine high grade PIN showed cytologic features identical to the human counterpart, including cell crowding, loss of polarity, and nuclear and nucleolar enlargement. Foci of high grade PIN were present in the prostates of 6 of 11 (55%) elderly, sexually intact dogs but only 1 of 13 (8%) dogs less than 4 years old. Foci of high grade PIN were detected in 1 of 11 (9%) elderly castrated dogs. In elderly, sexually intact dogs with PIN, foci of high grade PIN were present in 13 of 83 (16%) tissue sections evaluated; one of these dogs had focal adenocarcinoma in addition to PIN. Conclusions: These results indicate that high grade PIN is frequently present in the prostate of elderly, sexually intact dogs. The prevalence of canine PIN, like human PIN, is apparently influenced by age and testicular androgens. The canine prostate may serve as a useful model to determine the factors that regulate the apparent progression from benign epithelium to PIN and invasive carcinoma. References 1 : Report of the committee on staging and pathology. Cancer1992; 70: 359. Google Scholar 2 : High grade prostatic intraepithelial neoplasia: the most likely precursor of prostate cancer. Cancer1995; 75: 1823. Google Scholar 3 : Prostatic intra-epithelial neoplasia and early invasion in prostate cancer. Cancer1987; 59: 788. Google Scholar 4 : Prostatic intra-epithelial neoplasia: expression and location of proliferating cell nuclear antigen in epithelial, endothelial and stromal nuclei. Virchows Archiv. [A] Pathol. Anat.1993; 422: 185. Google Scholar 5 : Prostatic intra-epithelial neoplasia: qualitative and quantitative analyses of the blood capillary architecture on thin tissue sections. Pathol. Res. Pract.1993; 189: 542. Google Scholar 6 : Molecular biology of prostatic intraepithelial neoplasia. Prostate1996; 29: 117. Google Scholar 7 : Intraductal dysplasia: a premalignant lesion of the prostate. Hum. Pathol.1986; 17: 64. Crossref, Medline, Google Scholar 8 : Significance of prostatic intraepithelial neoplasia on prostate needle biopsy. Urology1991; 38: 103. Crossref, Medline, Google Scholar 9 : Prostatic intraepithelial neoplasia is a risk factor for adenocarcinoma: predictive accuracy in needle biopsies. J. Urol.1995; 154: 1295. Link, Google Scholar 10 : Adenocarcinoma of the canine prostate. Cancer1968; 22: 1329. Google Scholar 11 : The influence of castration on the development of prostatic carcinoma in the dog. J. Vet. Intern. Med.1987; 1: 183. Google Scholar 12 : Clinical and pathologic features of prostatic adenocarcinoma in sexually intact and castrated dogs: 31 cases (1970-1987). J. Am. Vet. Med. Assoc.1988; 199: 1623. Google Scholar 13 : Studies on the canine prostate gland. II. Prostatic neoplasms. J. Comp. Pathol.1963; 73: 244. Google Scholar 14 : Prostatic intraepithelial neoplasia in dogs with spontaneous prostate cancer. Prostate1996; . (in press). Google Scholar 15 Medical Uses of Statistics. Edited by . Boston: NEJM Books1992. Google Scholar 16 : An alternative to laboratory animal experimentation for human health risk assessment: epidemiological studies of pet animals. ATLA1986; 13: 267. Google Scholar 17 : The frequency of carcinoma and intraepithelial neoplasia of the prostate in young male patients. J. Urol.1993; 150: 379. Link, Google Scholar 18 : High grade prostatic intraepithelial neoplasia (HGPIN) and prostatic adenocarcinoma between the ages of 20-69: an autopsy study of 249 cases. In Vivo1994; 8: 439. Google Scholar 19 : The extent and multicentricity of high grade prostatic intraepithelial neoplasia in clinically localized prostatic adenocarcinoma. Human Pathol.1995; . (in press).. Google Scholar 20 : Large acinar atypical hyperplasia and carcinoma of the prostate. Cancer1988; 61: 555. Google Scholar 21 : Decrease of prostatic intraepithelial neoplasia (PIN) following androgen deprivation therapy in patients with stage T3 carcinoma treated by radical prostatectomy. Urology1994; 44: 91. Google Scholar 22 : Occurrence of cell death (apoptosis) in prostatic intraepithelial neoplasia. Virch. Arch. [A] Pathol. Anat.1993; 423: 351. Google Scholar 23 : Biochemical alterations in sex hormone-induced hyperplasia and dysplasia of the dorsolateral prostates of Noble rats. J. Natl. Cancer Inst.1988; 80: 1045. Google Scholar 24 : Prostatic dysplasia associated with increased expression of c-myc in neonatally estrogenized mice. J. Urol.1993; 149: 1593. Abstract, Google Scholar 25 : Histogenesis of induced prostate and seminal vesicle carcinoma in Lobund-Wistar rats: a system for histological scoring and grading. Cancer Res.1994; 54: 1440. Google Scholar Cancer Biology Laboratory, Purdue University, West Lafayette, Indiana, and Department of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, Minnesota.© 1997 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 157Issue 2February 1997Page: 713-716 Advertisement Copyright & Permissions© 1997 by American Urological Association, Inc.MetricsAuthor Information David J. Waters More articles by this author David G. Bostwick More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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