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- W2088402523 abstract "Objective: The aim of this study was to evaluate a new technique of ultrasonographic assessment of biliary tract response on fatty meal test with isosorbide dinitrate in patients with various gastrointestinal disorders. Methods: To select patients for evaluation of modified ultrasonographic fatty meal test, a retrospective analysis of clinical, instrumental, and conventional ultrasonographic data of 340 patients, hospitalized in the gastroenterological department, was performed. There were 120 patients with bulbar localization of peptic ulcer (PU), 70 patients with chronic pancreatitis (CP), 60 with gastro-esophageal reflux disease (GORD), and 90 with chronic gastritis, type C (CGC). The modifications of fatty meal test were: 1) basal multimetric measurements of gallbladder (GB), common bile duct diameters, and volume every 20 minutes during the period of 2 hours after fatty meal breakfast, including calculation not only of the rate of GB contraction, but also of relaxation; 2) next day repetition of fatty meal test with isosorbide dinitrate (10 mg per os 40 minutes before breakfast), which allows to detect reversibility of disorders. Results: The retrospective analysis revealed that hyperkinetic disturbances in choledynamics can be seen in 82.0% of patients with PU, 46.6% with CP, 75.2% with GORD, and 85.5% with CGC. 45 of analyzed patients were selected for modified repeated fatty meal test with isosorbide dinitrate. The structure of pathology was: 18 patients with PU, 12 with CP, and 15 with CGC. When analyzing results of modified fatty meal test, we found that in 4 (22.2%) patients with CU, 8 (66.7%) with CP, and 6 (40.0%) with CGC, the basal rate of GB relaxation was significantly decreased. During next day isosorbide dinitrate test, normalization of this parameter was registered in 15 (83.3%) of these patients. Conclusions: This pilot study demonstrates that ultrasonographic two-phase fatty meal test with isosorbide dinitrate can become a new interesting approach to assess abnormalities of choledynamics and their reversibility in patients with gastrointestinal diseases. Detection of these abnormalities may lead to differentiation and optimization of therapy." @default.
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- W2088402523 date "2003-05-01" @default.
- W2088402523 modified "2023-10-06" @default.
- W2088402523 title "New ultrasonographic fatty meal test with isosorbide dinitrate in assessment of choledynamics in patients with gastrointestinal diseases" @default.
- W2088402523 doi "https://doi.org/10.1016/s0301-5629(03)00503-9" @default.
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