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- W2088404639 abstract "The specificity of IgM isotype response directed against the putative core of hepatitis C virus (HCV core IgM) was demonstrated in HCV IgM EIA reactive samples. No interference was noted when samples with increasing levels of rheumatoid factor (RF) alone, or in combination with graded concentrations of anti-HCV IgG (HCV IgG), were tested. No deterioration in assay specificity was seen in 30 sera from patients with monoclonal gammapathies (all isotypes). With Protein G affinity chromatography, RF/HCV IgG immune complexes and HCV core IgM antibodies displayed different binding characteristics, HCV core IgM appeared in the buffer eluate while HCV IgG/RF remained bound. With sucrose density gradient centrifugation HCV core IgM sedimented at 17–19S." @default.
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- W2088404639 date "1996-05-01" @default.
- W2088404639 modified "2023-09-23" @default.
- W2088404639 title "Demonstration of specific detection of anti-HCV IgM core antibodies" @default.
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- W2088404639 doi "https://doi.org/10.1016/0166-0934(96)02030-7" @default.
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