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- W2088406470 abstract "We have prepared new hyaluronan (HA) gadolinium diethylenetriaminepentaacetic acid (DTPA) conjugates that have potential as tumor specific contrast agents for magnetic resonance imaging. Conjugates were synthesized, starting with a high molecular weight HA or with HA oligomers, by an efficient 2-step procedure involving first, reaction of ethylenediamine with HA carboxylic acid groups and, second, covalent linkage of DTPA to aminated HA. The final polymers were compared in terms of molar masses and DTPA content. Tapping mode atomic force microscopy has been used to examine the morphology of the polymers in aqueous solution." @default.
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- W2088406470 date "2002-08-01" @default.
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- W2088406470 title "Gadolinium diethylenetriaminepentaacetic acid hyaluronan conjugates: preparation, properties and applications" @default.
- W2088406470 doi "https://doi.org/10.1002/1521-3900(200208)186:1<105::aid-masy105>3.0.co;2-2" @default.
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