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- W2088406916 abstract "A practical synthesis of (2R,3S)- and (2S,3R)-β-methyltryptophan ethyl ester (β-MeTrp-OEt) has been developed. Racemic threo-β-MeTrp-OEt was diastereoselectively prepared via crystallization-induced diastereomer transformation (CIDT) of the α-nitro equivalent of β-MeTrp-OEt. The enantiomers were resolved via diastereomeric salt formation using a half equivalent of (R)-2-(4-hydroxyphenoxy)propionic acid. The process allowed a diabetes drug candidate N-[(1R,2S)-1-({5-[(dimethylamino)methyl]-2-ethoxyphenyl}aminocarbonyl)-2-(1H-indol-3-yl)propyl]-4-phenyl-1-piperidinecarboxamide to be prepared in good yield with high quality." @default.
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- W2088406916 date "2009-08-01" @default.
- W2088406916 modified "2023-09-27" @default.
- W2088406916 title "A practical synthesis of enantiopure β-methyltryptophan ethyl ester for a preparation of diabetes drug" @default.
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- W2088406916 doi "https://doi.org/10.1016/j.tet.2009.06.027" @default.
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