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• W2088407598 startingPage "5351" @default.
• W2088407598 abstract "The transcriptional activation potential of proteins can be assayed in chimeras containing a heterologous DNA-binding domain that mediates their recruitment to reporter genes. This approach has been widely used in yeast and in transient mammalian cell assays. Here, we applied it to assay the transactivation potential of proteins in transgenic Drosophila embryos. We found that a chimera between the DNA-binding bacterial LexA protein and the transactivation domain from yeast GAL4 behaved as a potent synthetic activator in all embryonic tissues. In contrast, a LexA chimera containing Drosophila Fos (Dfos) required an unexpected degree of context to function as a transcriptional activator. We provide evidence to suggest that this context is provided by Djun and Mad (a Drosophila Smad), and that these partner factors need to be activated by signaling from Jun N-terminal kinase and decapentaplegic, respectively. Because Dfos behaves as an autonomous transcriptional activator in more artificial assays systems, our data suggest that context-dependence of transcription factors may be more prevalent than previously thought." @default.
• W2088407598 created "2016-06-24" @default.
• W2088407598 creator A5053820033 @default.
• W2088407598 creator A5084496847 @default.
• W2088407598 date "2000-05-09" @default.
• W2088407598 modified "2023-10-04" @default.
• W2088407598 title "LexA chimeras reveal the function of <i>Drosophila</i> Fos as a context-dependent transcriptional activator" @default.
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• W2088407598 doi "https://doi.org/10.1073/pnas.97.10.5351" @default.
• W2088407598 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/25832" @default.
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