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- W2088410605 abstract "Polypyrimidine Tract Binding protein (PTB) is a key alternative splicing factor involved in exon repression. It has been proposed that PTB acts by looping out exons flanked by pyrimidine-tracts. We present fluorescence, NMR and in vivo splicing data that directly support this mechanism. We show that the RNA recognition domains (RRM) 3 and 4 of PTB can bind two distant pyrimidine-tracts and bring their 5′ and 3′ ends in close proximity, thus looping the RNA. Looping efficiency depends on the length of the intervening sequence with preference for a 15 nucleotides spacer or longer between the pyrimidine-tracts. RRMs 3 and 4 bind the 5′ and the 3′ pyrimidine-tracts, respectively, in a specific directionality, and work synergistically for efficient RNA looping in vivo." @default.
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- W2088410605 date "2010-01-01" @default.
- W2088410605 modified "2023-09-28" @default.
- W2088410605 title "RNA Looping By PTB: Evidence Using Fret and NMR Spectroscopy and For a Role in Splicing Repression" @default.
- W2088410605 doi "https://doi.org/10.1016/j.bpj.2009.12.411" @default.
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