Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088433073> ?p ?o ?g. }
- W2088433073 endingPage "519" @default.
- W2088433073 startingPage "508" @default.
- W2088433073 abstract "Abnormal phosphorylation contributes to the formation of neurofibrillary tangles in Alzheimer's disease (AD), but may play other signaling roles during AD pathogenesis. In this study, we employed IMAC followed by LC‐MS/MS to identify phosphopeptides from eight individual AD and eight age‐matched control postmortem human brain tissues. Using this approach, we identified 5569 phosphopeptides in frontal cortex across all 16 cases in which phosphopeptides represented 80% of all peptide spectral counts collected following IMAC enrichment. Marker selection identified 253 significantly altered phosphopeptides by precursor intensity, changed by at least 1.75‐fold relative to controls, with an empirical false discovery rate below 7%. Approximately 21% of all significantly altered phosphopeptides in AD tissue were derived from tau. Of the other 142 proteins hyperphosphorylated in AD, membrane, synapse, cell junction, and alternatively spliced proteins were overrepresented. Of these, we validated differential phosphorylation of HSP 27 (HSPB1) and crystallin‐alpha‐B (CRYAB) as hyperphosphorylated by Western blotting. We further identified a network of phosphorylated kinases, which coenriched with phosphorylated small HSPs. This supports a hypothesis that a number of kinases are regulating and/or regulated by the small HSP folding network." @default.
- W2088433073 created "2016-06-24" @default.
- W2088433073 creator A5022349887 @default.
- W2088433073 creator A5023920651 @default.
- W2088433073 creator A5043231378 @default.
- W2088433073 creator A5054941736 @default.
- W2088433073 creator A5061526409 @default.
- W2088433073 creator A5063529297 @default.
- W2088433073 creator A5080612573 @default.
- W2088433073 date "2014-12-17" @default.
- W2088433073 modified "2023-10-01" @default.
- W2088433073 title "Quantitative phosphoproteomics of Alzheimer's disease reveals cross‐talk between kinases and small heat shock proteins" @default.
- W2088433073 cites W1538925875 @default.
- W2088433073 cites W1964569672 @default.
- W2088433073 cites W1966327575 @default.
- W2088433073 cites W1967524093 @default.
- W2088433073 cites W1968611669 @default.
- W2088433073 cites W1971233962 @default.
- W2088433073 cites W1979800575 @default.
- W2088433073 cites W1993450321 @default.
- W2088433073 cites W1999008576 @default.
- W2088433073 cites W1999916343 @default.
- W2088433073 cites W2005809709 @default.
- W2088433073 cites W2007408621 @default.
- W2088433073 cites W2012917547 @default.
- W2088433073 cites W2019287022 @default.
- W2088433073 cites W2019962936 @default.
- W2088433073 cites W2022675211 @default.
- W2088433073 cites W2022812411 @default.
- W2088433073 cites W2030205108 @default.
- W2088433073 cites W2034286717 @default.
- W2088433073 cites W2038431416 @default.
- W2088433073 cites W2040250464 @default.
- W2088433073 cites W2040614271 @default.
- W2088433073 cites W2044763315 @default.
- W2088433073 cites W2045609352 @default.
- W2088433073 cites W2053880389 @default.
- W2088433073 cites W2065530902 @default.
- W2088433073 cites W2069570898 @default.
- W2088433073 cites W2070411510 @default.
- W2088433073 cites W2073128231 @default.
- W2088433073 cites W2074527824 @default.
- W2088433073 cites W2079821580 @default.
- W2088433073 cites W2087608585 @default.
- W2088433073 cites W2096057003 @default.
- W2088433073 cites W2103386246 @default.
- W2088433073 cites W2106568456 @default.
- W2088433073 cites W2118208022 @default.
- W2088433073 cites W2129677617 @default.
- W2088433073 cites W2131981022 @default.
- W2088433073 cites W2133465414 @default.
- W2088433073 cites W2137576652 @default.
- W2088433073 cites W2148570557 @default.
- W2088433073 cites W2158217645 @default.
- W2088433073 cites W2158920723 @default.
- W2088433073 cites W4247759744 @default.
- W2088433073 cites W2058677139 @default.
- W2088433073 doi "https://doi.org/10.1002/pmic.201400189" @default.
- W2088433073 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4404162" @default.
- W2088433073 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25332170" @default.
- W2088433073 hasPublicationYear "2014" @default.
- W2088433073 type Work @default.
- W2088433073 sameAs 2088433073 @default.
- W2088433073 citedByCount "73" @default.
- W2088433073 countsByYear W20884330732014 @default.
- W2088433073 countsByYear W20884330732015 @default.
- W2088433073 countsByYear W20884330732016 @default.
- W2088433073 countsByYear W20884330732017 @default.
- W2088433073 countsByYear W20884330732018 @default.
- W2088433073 countsByYear W20884330732019 @default.
- W2088433073 countsByYear W20884330732020 @default.
- W2088433073 countsByYear W20884330732021 @default.
- W2088433073 countsByYear W20884330732022 @default.
- W2088433073 countsByYear W20884330732023 @default.
- W2088433073 crossrefType "journal-article" @default.
- W2088433073 hasAuthorship W2088433073A5022349887 @default.
- W2088433073 hasAuthorship W2088433073A5023920651 @default.
- W2088433073 hasAuthorship W2088433073A5043231378 @default.
- W2088433073 hasAuthorship W2088433073A5054941736 @default.
- W2088433073 hasAuthorship W2088433073A5061526409 @default.
- W2088433073 hasAuthorship W2088433073A5063529297 @default.
- W2088433073 hasAuthorship W2088433073A5080612573 @default.
- W2088433073 hasBestOaLocation W20884330732 @default.
- W2088433073 hasConcept C104317684 @default.
- W2088433073 hasConcept C11960822 @default.
- W2088433073 hasConcept C127445978 @default.
- W2088433073 hasConcept C169760540 @default.
- W2088433073 hasConcept C184235292 @default.
- W2088433073 hasConcept C185592680 @default.
- W2088433073 hasConcept C203014093 @default.
- W2088433073 hasConcept C205260736 @default.
- W2088433073 hasConcept C2780942790 @default.
- W2088433073 hasConcept C51551487 @default.
- W2088433073 hasConcept C55493867 @default.
- W2088433073 hasConcept C57074206 @default.
- W2088433073 hasConcept C6675166 @default.
- W2088433073 hasConcept C85265743 @default.
- W2088433073 hasConcept C86803240 @default.