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- W2088444983 abstract "Abstract The pharmacokinetic parameters of MHGH22K, such as the mean values of t 1 2 (9.30, 16.8, 22.2 vs 25.8 min), MRT (11.6, 21.7, 26.7 vs 37.9 min) and Vss (166, 218, 342 vs 556 ml kg−1) tended to increase with increasing doses after i.v. administration of the hormone (0.2, 0.5, 2.0 and 5.0 U kg−1) to rabbits. However, the mean values of CL, CLR and CLNR were dose-independent over the dose ranges studied, indicating that the dose-dependent pharmacokinetic parameters of MHGH22K, such as t 1 2 , MRT and Vssmay not be due to the saturable metabolism of the hormone. The extent of bioavailability after s.c. administration of MHGH22K (0.5 U kg−1) to rabbits appeared to be complete when compared with the AUC values between i.v. and s.c. administration at the same dose. MHGH22K was highly concentrated in the kidney and liver (T/P ratio greater than unity), whereas lower levels were observed in the other tissues or organs studied at 2 h after s.c. administration of the hormone (0.5 U kg−1) to rabbits." @default.
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- W2088444983 date "1993-02-01" @default.
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- W2088444983 title "Pharmacokinetics of a 22 kDa variant of unlabelled monomeric human growth hormone in rabbits" @default.
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- W2088444983 doi "https://doi.org/10.1016/0378-5173(93)90298-t" @default.
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