Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088462025> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2088462025 abstract "microvascular disease (MVD) is limited. We tested the association between HDL-C and MVD using prospective data from a large clinical trial of type 2 diabetics. Methods: 11,126 type 2 diabetics with ≥1 vascular risk factor were followed an average of 4.8 years. Cox proportional hazard models, adjusted for a wide range of covariates,wereused to assess baselineHDL-Canddevelopment of new/worseningMVD; defined prospectively as a composite of total renal events (new/worsening albuminuria, doubling of creatinine ≥200 mol/L, need for dialysis or death due to renal disease) and total eye events (new proliferative retinopathy, macular oedema, need for photocoagulation-therapy or diabetes-related blindness). Results: During follow-up, 32% of patients developed neworworseningMVD (28% renal and 6% retinal events). In patients who developed MVD compared to those who did not, mean baseline HDL-C was slightly lower (1.25± 0.35mmol/L versus 1.26± 0.35mmol/L, p= 0.05). For each 0.4mmol/L (1 SD) higher baseline HDL-C there was a significant 5% decrease in MVD (adjusted HR=0.95, 95%CI 0.91–0.99, p= 0.02), primarily driven by a 6%decrease in the risk of renal events (adjustedHR=0.94, 95%CI 0.90–0.99, p= 0.01). There was no such association between baseline HDL-C and retinal events (adjusted HR=1.02, 95%CI 0.92–1.12, p= 0.7). Conclusions: In patients with type 2 diabetes HDL-C level is an independent risk factor for the development of renal events, but not retinal events. doi:10.1016/j.hlc.2011.05.134" @default.
- W2088462025 created "2016-06-24" @default.
- W2088462025 creator A5023362583 @default.
- W2088462025 creator A5025399548 @default.
- W2088462025 creator A5027484988 @default.
- W2088462025 creator A5033017068 @default.
- W2088462025 creator A5049080356 @default.
- W2088462025 creator A5053198456 @default.
- W2088462025 creator A5073990841 @default.
- W2088462025 date "2011-01-01" @default.
- W2088462025 modified "2023-09-28" @default.
- W2088462025 title "High Long Term Success Rates for Statin Rechallenge in Patients Referred for Statin Intolerance" @default.
- W2088462025 doi "https://doi.org/10.1016/j.hlc.2011.05.136" @default.
- W2088462025 hasPublicationYear "2011" @default.
- W2088462025 type Work @default.
- W2088462025 sameAs 2088462025 @default.
- W2088462025 citedByCount "0" @default.
- W2088462025 crossrefType "journal-article" @default.
- W2088462025 hasAuthorship W2088462025A5023362583 @default.
- W2088462025 hasAuthorship W2088462025A5025399548 @default.
- W2088462025 hasAuthorship W2088462025A5027484988 @default.
- W2088462025 hasAuthorship W2088462025A5033017068 @default.
- W2088462025 hasAuthorship W2088462025A5049080356 @default.
- W2088462025 hasAuthorship W2088462025A5053198456 @default.
- W2088462025 hasAuthorship W2088462025A5073990841 @default.
- W2088462025 hasBestOaLocation W20884620251 @default.
- W2088462025 hasConcept C126322002 @default.
- W2088462025 hasConcept C134018914 @default.
- W2088462025 hasConcept C159641895 @default.
- W2088462025 hasConcept C188816634 @default.
- W2088462025 hasConcept C207103383 @default.
- W2088462025 hasConcept C2776174234 @default.
- W2088462025 hasConcept C2776839432 @default.
- W2088462025 hasConcept C2777180221 @default.
- W2088462025 hasConcept C2778313320 @default.
- W2088462025 hasConcept C2778653478 @default.
- W2088462025 hasConcept C2779829184 @default.
- W2088462025 hasConcept C2779978075 @default.
- W2088462025 hasConcept C2780306776 @default.
- W2088462025 hasConcept C44249647 @default.
- W2088462025 hasConcept C50382708 @default.
- W2088462025 hasConcept C50440223 @default.
- W2088462025 hasConcept C555293320 @default.
- W2088462025 hasConcept C71924100 @default.
- W2088462025 hasConcept C90924648 @default.
- W2088462025 hasConceptScore W2088462025C126322002 @default.
- W2088462025 hasConceptScore W2088462025C134018914 @default.
- W2088462025 hasConceptScore W2088462025C159641895 @default.
- W2088462025 hasConceptScore W2088462025C188816634 @default.
- W2088462025 hasConceptScore W2088462025C207103383 @default.
- W2088462025 hasConceptScore W2088462025C2776174234 @default.
- W2088462025 hasConceptScore W2088462025C2776839432 @default.
- W2088462025 hasConceptScore W2088462025C2777180221 @default.
- W2088462025 hasConceptScore W2088462025C2778313320 @default.
- W2088462025 hasConceptScore W2088462025C2778653478 @default.
- W2088462025 hasConceptScore W2088462025C2779829184 @default.
- W2088462025 hasConceptScore W2088462025C2779978075 @default.
- W2088462025 hasConceptScore W2088462025C2780306776 @default.
- W2088462025 hasConceptScore W2088462025C44249647 @default.
- W2088462025 hasConceptScore W2088462025C50382708 @default.
- W2088462025 hasConceptScore W2088462025C50440223 @default.
- W2088462025 hasConceptScore W2088462025C555293320 @default.
- W2088462025 hasConceptScore W2088462025C71924100 @default.
- W2088462025 hasConceptScore W2088462025C90924648 @default.
- W2088462025 hasLocation W20884620251 @default.
- W2088462025 hasOpenAccess W2088462025 @default.
- W2088462025 hasPrimaryLocation W20884620251 @default.
- W2088462025 hasRelatedWork W1531888305 @default.
- W2088462025 hasRelatedWork W1966003062 @default.
- W2088462025 hasRelatedWork W2020867461 @default.
- W2088462025 hasRelatedWork W2118184073 @default.
- W2088462025 hasRelatedWork W2290385107 @default.
- W2088462025 hasRelatedWork W2413831422 @default.
- W2088462025 hasRelatedWork W2414368128 @default.
- W2088462025 hasRelatedWork W2591865226 @default.
- W2088462025 hasRelatedWork W2767569336 @default.
- W2088462025 hasRelatedWork W2886998943 @default.
- W2088462025 hasRelatedWork W2899578298 @default.
- W2088462025 hasRelatedWork W2951530638 @default.
- W2088462025 hasRelatedWork W2981260345 @default.
- W2088462025 hasRelatedWork W2990088494 @default.
- W2088462025 hasRelatedWork W2995179743 @default.
- W2088462025 hasRelatedWork W3010722903 @default.
- W2088462025 hasRelatedWork W3015168671 @default.
- W2088462025 hasRelatedWork W3036177780 @default.
- W2088462025 hasRelatedWork W3037901577 @default.
- W2088462025 hasRelatedWork W3042379056 @default.
- W2088462025 isParatext "false" @default.
- W2088462025 isRetracted "false" @default.
- W2088462025 magId "2088462025" @default.
- W2088462025 workType "article" @default.