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• W2088462886 abstract "Choline and the related compounds phosphocholine (PC) and glycerophosphocholine (GPC) are considered to be important metabolites in oncology. Past studies have demonstrated correlations linking the relative ratios and concentrations of these metabolites with the development and progression of cancer. Currently, in vivo and tissue ex vivo magnetic resonance spectroscopy methods have mostly centered on measuring the total concentration of these metabolites and have difficulty in differentiating between them. Here, a new scheme that uses (31)P edited (1)H spectroscopy to quantify the concentrations of choline, PC and GPC in biological samples is reported and its applicability is demonstrated using samples of human brain tumor extracts. This method is particularly well-suited for analytical situations where the PC and GPC resonances are not sufficiently resolved and/or are obscured by other metabolites. Consequently, this scheme has the potential to be used for the analysis of choline compounds in ex vivo tissue samples." @default.
• W2088462886 created "2016-06-24" @default.
• W2088462886 creator A5007200182 @default.
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• W2088462886 creator A5047091139 @default.
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• W2088462886 date "2005-11-01" @default.
• W2088462886 modified "2023-10-05" @default.
• W2088462886 title "Quantification of phosphocholine and glycerophosphocholine with31P edited1H NMR spectroscopy" @default.
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• W2088462886 doi "https://doi.org/10.1002/nbm.973" @default.
• W2088462886 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16075415" @default.
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