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- W2088472470 abstract "Dose-dependency in theophylline pharmacokinetics and protein binding characteristics was examined in 10 healthy male volunteers. Theophylline disposition was determined after an intravenous infusion of both 1 mg/kg and 6 mg/kg aminophylline in a randomised crossover study. There was considerable intrasubject variability in theophylline clearance but no significant dose-dependency. Theophylline protein binding was assessed by equilibrium dialysis at varying theophylline concentrations. The percentage of free non-protein bound theophylline was significantly increased at high theophylline concentrations. This increase in free theophylline would lead to a non-linear increase in the risk of toxicity with increasing drug concentration." @default.
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- W2088472470 date "1981-05-01" @default.
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- W2088472470 title "Dose-dependency of theophylline clearance and protein binding." @default.
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- W2088472470 doi "https://doi.org/10.1136/thx.36.5.382" @default.
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