FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088474136> ?p ?o ?g. }

• W2088474136 endingPage "1623" @default.
• W2088474136 startingPage "1613" @default.
• W2088474136 abstract "Death receptors, such as Fas/CD95 and TRAIL receptors, engage the extrinsic pathway for caspase activation, but also couple to the intrinsic mitochondrial route. In so-called Type II cells, death receptors require the mitochondrial pathway for apoptotic execution, whereas in Type I cells they reportedly do not. For established tumor cell lines, the Type I/Type II distinction is based on short-term apoptosis assays. We report here that the mitochondrial pathway is essential for apoptotic execution of Type I tumor cells by death receptors, when long-term clonogenicity is taken into account. A blockade of the mitochondrial pathway in Type I tumor cells – by RNA interference for Bid or Bcl-2 overexpression – reduced effector caspase activity and mediated significant clonogenic resistance to TRAIL. Downstream from the mitochondria, Caspase-9 did not contribute to clonogenic death of TRAIL-treated Type I cells. Rather, the release of Smac/DIABLO and the inhibition of XIAP activity proved to be crucial for full effector caspase activity and clonogenic execution. Thus, in Type I cells the intrinsic pathway downstream from death receptors is not redundant, but limits clonogenicity by virtue of Smac/DIABLO release and XIAP inhibition. This finding is relevant for cancer therapy using death receptor agonists." @default.
• W2088474136 created "2016-06-24" @default.
• W2088474136 creator A5016828687 @default.
• W2088474136 creator A5018839824 @default.
• W2088474136 creator A5027596320 @default.
• W2088474136 creator A5028840794 @default.
• W2088474136 creator A5043109227 @default.
• W2088474136 creator A5047718069 @default.
• W2088474136 creator A5058680680 @default.
• W2088474136 date "2010-04-16" @default.
• W2088474136 modified "2023-10-18" @default.
• W2088474136 title "Smac/DIABLO release from mitochondria and XIAP inhibition are essential to limit clonogenicity of Type I tumor cells after TRAIL receptor stimulation" @default.
• W2088474136 cites W1527985047 @default.
• W2088474136 cites W1587890084 @default.
• W2088474136 cites W1593219141 @default.
• W2088474136 cites W1618299283 @default.
• W2088474136 cites W1966798559 @default.
• W2088474136 cites W1967894078 @default.
• W2088474136 cites W1973109581 @default.
• W2088474136 cites W1984547206 @default.
• W2088474136 cites W1985834051 @default.
• W2088474136 cites W1995264271 @default.
• W2088474136 cites W1996174406 @default.
• W2088474136 cites W1998198750 @default.
• W2088474136 cites W2000352412 @default.
• W2088474136 cites W2000601138 @default.
• W2088474136 cites W2001817269 @default.
• W2088474136 cites W2004611844 @default.
• W2088474136 cites W2012173926 @default.
• W2088474136 cites W2012825099 @default.
• W2088474136 cites W2019450833 @default.
• W2088474136 cites W2020439083 @default.
• W2088474136 cites W2026873116 @default.
• W2088474136 cites W2042409437 @default.
• W2088474136 cites W2049873418 @default.
• W2088474136 cites W2053243170 @default.
• W2088474136 cites W2055946816 @default.
• W2088474136 cites W2061019845 @default.
• W2088474136 cites W2069407758 @default.
• W2088474136 cites W2083906562 @default.
• W2088474136 cites W2085184122 @default.
• W2088474136 cites W2090414390 @default.
• W2088474136 cites W2093475144 @default.
• W2088474136 cites W2096714217 @default.
• W2088474136 cites W2098641105 @default.
• W2088474136 cites W2111510713 @default.
• W2088474136 cites W2120473562 @default.
• W2088474136 cites W2123123035 @default.
• W2088474136 cites W2144654038 @default.
• W2088474136 cites W2149789119 @default.
• W2088474136 cites W2316070165 @default.
• W2088474136 doi "https://doi.org/10.1038/cdd.2010.39" @default.
• W2088474136 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20395960" @default.
• W2088474136 hasPublicationYear "2010" @default.
• W2088474136 type Work @default.
• W2088474136 sameAs 2088474136 @default.
• W2088474136 citedByCount "34" @default.
• W2088474136 countsByYear W20884741362012 @default.
• W2088474136 countsByYear W20884741362013 @default.
• W2088474136 countsByYear W20884741362014 @default.
• W2088474136 countsByYear W20884741362015 @default.
• W2088474136 countsByYear W20884741362016 @default.
• W2088474136 countsByYear W20884741362019 @default.
• W2088474136 countsByYear W20884741362020 @default.
• W2088474136 countsByYear W20884741362022 @default.
• W2088474136 countsByYear W20884741362023 @default.
• W2088474136 crossrefType "journal-article" @default.
• W2088474136 hasAuthorship W2088474136A5016828687 @default.
• W2088474136 hasAuthorship W2088474136A5018839824 @default.
• W2088474136 hasAuthorship W2088474136A5027596320 @default.
• W2088474136 hasAuthorship W2088474136A5028840794 @default.
• W2088474136 hasAuthorship W2088474136A5043109227 @default.
• W2088474136 hasAuthorship W2088474136A5047718069 @default.
• W2088474136 hasAuthorship W2088474136A5058680680 @default.
• W2088474136 hasBestOaLocation W20884741361 @default.
• W2088474136 hasConcept C117262875 @default.
• W2088474136 hasConcept C121608353 @default.
• W2088474136 hasConcept C170493617 @default.
• W2088474136 hasConcept C185592680 @default.
• W2088474136 hasConcept C190283241 @default.
• W2088474136 hasConcept C28859421 @default.
• W2088474136 hasConcept C31573885 @default.
• W2088474136 hasConcept C33195913 @default.
• W2088474136 hasConcept C48297814 @default.
• W2088474136 hasConcept C502942594 @default.
• W2088474136 hasConcept C51785407 @default.
• W2088474136 hasConcept C54355233 @default.
• W2088474136 hasConcept C55493867 @default.
• W2088474136 hasConcept C62478195 @default.
• W2088474136 hasConcept C86803240 @default.
• W2088474136 hasConcept C95444343 @default.
• W2088474136 hasConcept C96232424 @default.
• W2088474136 hasConcept C98424977 @default.
• W2088474136 hasConceptScore W2088474136C117262875 @default.
• W2088474136 hasConceptScore W2088474136C121608353 @default.
• W2088474136 hasConceptScore W2088474136C170493617 @default.
• W2088474136 hasConceptScore W2088474136C185592680 @default.
• W2088474136 hasConceptScore W2088474136C190283241 @default.

• next