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• W2088480894 abstract "Purposes: To evaluate the efficacy of topical 5-fluorouracil (5-FU) in treating conjunctival and corneal epithelial neoplasia. Methods: Three patients underwent surgical excision of bulky disease followed by topical 1 % 5-FU in artificial tear base for 2 to 3 weeks or until epithelial separation occurred. An additional three patients underwent treatment with topical 1 % 5-FU alone. Results: Minimum follow-up was 6 months. In one patient with conjunctival in situ carcinoma and no detectable normal conjunctiva, who had normal findings on conjunctival histologic examination after application of topical 5-FU, a focus of invasive disease requiring orbital exenteration. One patient had a favorable response to 5-FU therapy but required a repeat excision for control of bulky disease. Four patients have remained disease-free for 10, 13, 18, and 30 months after topical 5-FU therapy. Conclusion: With its potential selective toxicity on dysplastic epithelium, topical 5FU shows promise as an adjunctive treatment for managing conjunctival and corneal epithelial neoplasia. Purposes: To evaluate the efficacy of topical 5-fluorouracil (5-FU) in treating conjunctival and corneal epithelial neoplasia. Methods: Three patients underwent surgical excision of bulky disease followed by topical 1 % 5-FU in artificial tear base for 2 to 3 weeks or until epithelial separation occurred. An additional three patients underwent treatment with topical 1 % 5-FU alone. Results: Minimum follow-up was 6 months. In one patient with conjunctival in situ carcinoma and no detectable normal conjunctiva, who had normal findings on conjunctival histologic examination after application of topical 5-FU, a focus of invasive disease requiring orbital exenteration. One patient had a favorable response to 5-FU therapy but required a repeat excision for control of bulky disease. Four patients have remained disease-free for 10, 13, 18, and 30 months after topical 5-FU therapy. Conclusion: With its potential selective toxicity on dysplastic epithelium, topical 5FU shows promise as an adjunctive treatment for managing conjunctival and corneal epithelial neoplasia." @default.
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• W2088480894 date "1995-09-01" @default.
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• W2088480894 title "Topical 5-Fluorouracil in Treating Epithelial Neoplasia of the Conjunctiva and Cornea" @default.
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• W2088480894 doi "https://doi.org/10.1016/s0161-6420(95)30866-4" @default.
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