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- W2088486512 abstract "SUMMARY Foetal rat adrenals were grown in primary tissue culture. The effects of ethidium bromide on the adrenocorticotrophin (ACTH)-induced differentiation of the mitochondria of the cortical cells were examined. Ethidium bromide (1 μg/ml/day for 4 days) inhibited the morphological transformation of the mitochondria normally induced by ACTH. At the same time the steroid 11β-hydroxylating activity, which is associated with the inner mitochondrial membrane, was either partially or completely blocked. The ethidium bromide-treated cells contained mitochondria of varying sizes and with poorly developed inner membranes. The biochemical and morphological effects of ethidium bromide on the cortical cell mitochondria were only partially reversible." @default.
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- W2088486512 date "1972-03-01" @default.
- W2088486512 modified "2023-10-14" @default.
- W2088486512 title "CORTICOTROPHIN-INDUCED DIFFERENTIATION OF MITOCHONDRIA IN RAT ADRENAL CORTICAL CELLS GROWN IN PRIMARY TISSUE CULTURE: EFFECTS OF ETHIDIUM BROMIDE" @default.
- W2088486512 doi "https://doi.org/10.1677/joe.0.0520541" @default.
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