FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088497968> ?p ?o ?g. }

• W2088497968 endingPage "12" @default.
• W2088497968 startingPage "1" @default.
• W2088497968 abstract "The homologous ETV1, ETV4 and ETV5 proteins form the PEA3 subfamily of ETS transcription factors. In Ewing tumors, chromosomal translocations affecting ETV1 or ETV4 are an underlying cause of carcinogenesis. Likewise, chromosomal rearrangements of the ETV1, ETV4 or ETV5 gene occur in prostate tumors and are thought to be one of the major driving forces in the genesis of prostate cancer. In addition, these three ETS proteins are implicated in melanomas, breast and other types of cancer. Complex posttranslational modifications govern the activity of PEA3 factors, which can promote cell proliferation, motility and invasion. Here, we review evidence for a role of ETV1, 4 and 5 as oncoproteins and describe modes of their action. Modulation of their activation or interaction with cofactors as well as inhibiting crucial target gene products may ultimately be exploited to treat various cancers that are dependent on the PEA3 group of ETS transcription factors." @default.
• W2088497968 created "2016-06-24" @default.
• W2088497968 creator A5015042999 @default.
• W2088497968 creator A5046942450 @default.
• W2088497968 creator A5083818489 @default.
• W2088497968 date "2012-08-01" @default.
• W2088497968 modified "2023-10-16" @default.
• W2088497968 title "ETV1, 4 and 5: An oncogenic subfamily of ETS transcription factors" @default.
• W2088497968 cites W115673842 @default.
• W2088497968 cites W1525484196 @default.
• W2088497968 cites W1541544453 @default.
• W2088497968 cites W1564346420 @default.
• W2088497968 cites W1606273823 @default.
• W2088497968 cites W1963749564 @default.
• W2088497968 cites W1966205468 @default.
• W2088497968 cites W1967570424 @default.
• W2088497968 cites W1969951042 @default.
• W2088497968 cites W1972437632 @default.
• W2088497968 cites W1975487351 @default.
• W2088497968 cites W1976033223 @default.
• W2088497968 cites W1976677295 @default.
• W2088497968 cites W1977027014 @default.
• W2088497968 cites W1977038560 @default.
• W2088497968 cites W1977383995 @default.
• W2088497968 cites W1978716838 @default.
• W2088497968 cites W1980514987 @default.
• W2088497968 cites W1981301410 @default.
• W2088497968 cites W1982956833 @default.
• W2088497968 cites W1984814457 @default.
• W2088497968 cites W1985618133 @default.
• W2088497968 cites W1985781201 @default.
• W2088497968 cites W1988305905 @default.
• W2088497968 cites W1990100507 @default.
• W2088497968 cites W1990434941 @default.
• W2088497968 cites W1991164673 @default.
• W2088497968 cites W1993042966 @default.
• W2088497968 cites W1993420755 @default.
• W2088497968 cites W1995401663 @default.
• W2088497968 cites W1996375162 @default.
• W2088497968 cites W1996760634 @default.
• W2088497968 cites W1996988163 @default.
• W2088497968 cites W1998120891 @default.
• W2088497968 cites W1998947195 @default.
• W2088497968 cites W1999248691 @default.
• W2088497968 cites W2001778920 @default.
• W2088497968 cites W2004512249 @default.
• W2088497968 cites W2006619657 @default.
• W2088497968 cites W2007438323 @default.
• W2088497968 cites W2007760033 @default.
• W2088497968 cites W2010979064 @default.
• W2088497968 cites W2011395706 @default.
• W2088497968 cites W2011547492 @default.
• W2088497968 cites W2012268660 @default.
• W2088497968 cites W2012427472 @default.
• W2088497968 cites W2013108773 @default.
• W2088497968 cites W2013503399 @default.
• W2088497968 cites W2015009944 @default.
• W2088497968 cites W2015437876 @default.
• W2088497968 cites W2016371780 @default.
• W2088497968 cites W2018825948 @default.
• W2088497968 cites W2018849561 @default.
• W2088497968 cites W2019320203 @default.
• W2088497968 cites W2019364309 @default.
• W2088497968 cites W2023011880 @default.
• W2088497968 cites W2027899965 @default.
• W2088497968 cites W2028781081 @default.
• W2088497968 cites W2029169609 @default.
• W2088497968 cites W2029421262 @default.
• W2088497968 cites W2029575024 @default.
• W2088497968 cites W2030465046 @default.
• W2088497968 cites W2037579198 @default.
• W2088497968 cites W2038516748 @default.
• W2088497968 cites W2039504258 @default.
• W2088497968 cites W2040004396 @default.
• W2088497968 cites W2040729471 @default.
• W2088497968 cites W2041140906 @default.
• W2088497968 cites W2041425187 @default.
• W2088497968 cites W2043927273 @default.
• W2088497968 cites W2049205984 @default.
• W2088497968 cites W2050517163 @default.
• W2088497968 cites W2052137302 @default.
• W2088497968 cites W2052215025 @default.
• W2088497968 cites W2052947465 @default.
• W2088497968 cites W2053073820 @default.
• W2088497968 cites W2054740212 @default.
• W2088497968 cites W2056031203 @default.
• W2088497968 cites W2059555876 @default.
• W2088497968 cites W2062009057 @default.
• W2088497968 cites W2067253161 @default.
• W2088497968 cites W2067598275 @default.
• W2088497968 cites W2070223839 @default.
• W2088497968 cites W2074214732 @default.
• W2088497968 cites W2074334235 @default.
• W2088497968 cites W2076111240 @default.
• W2088497968 cites W2077587582 @default.
• W2088497968 cites W2078921740 @default.
• W2088497968 cites W2079126104 @default.
• W2088497968 cites W2079298594 @default.

• next