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• W2088503713 abstract "Bacterial products, including lipopolysaccharide (LPS), are potential impurities in plasmid DNA vaccines. LPS has immunostimulatory properties even at exceedingly low concentrations through activation of Toll-like receptor 4 (TLR4). The potency of T-cell responses after vaccination was tested with DNA containing high LPS or depleted of LPS in TLR4-competent and TLR4-deficient mice. CD8(+) T-cell responses were readily induced in TLR4-deficient mice immunized with DNA depleted of LPS. LPS in DNA vaccines is not required for CD8(+) T-cell responses." @default.
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• W2088503713 date "2003-03-01" @default.
• W2088503713 modified "2023-09-26" @default.
• W2088503713 title "The role of lipopolysaccharide in T-cell responses following DNA vaccination" @default.
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• W2088503713 doi "https://doi.org/10.1016/s0264-410x(02)00676-x" @default.
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