Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088513628> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2088513628 endingPage "1174" @default.
- W2088513628 startingPage "1169" @default.
- W2088513628 abstract "Background and Purpose: Corticosteroids have been commonly used in medical expulsive therapy for obstructing ureteral calculi. The exact mechanism of action responsible for facilitation of stone expulsion is unknown, but it is attributed to the anti-inflammatory properties of corticosteroids. Corticosteroids inhibit the production of phospholipase A2 and cyclooxygenase-2, both of which are involved in prostaglandin synthesis. We sought to determine if hydrocortisone inhibits ureteral contractility directly by assessing its action in an isolated in vitro contractility assay. Methods: Porcine ureters were attached to force displacement transducers and suspended in organ tissue baths containing aerated Krebs buffer. Tissues were equilibrated for 1 hour, and a spontaneous contractility rate was established. After equilibration, tissues were incubated with a 10-fold concentration curve of hydrocortisone (1 nM–10 μM) for 90 minutes, and compared with indomethacin (1 μM) and dimethyl sulfoxide (DMSO) 0.1% as positive and negative controls of contraction, respectively. Contractility rates were recorded on a polygraph and analyzed for changes over exposure time during the course of the experiment. Results: Hydrocortisone inhibited ureteral contractility in a concentration dependent trend. After 90 minutes of treatment, 100 nM, 1 μM, and 10 μM all produced a statistically significant decrease in ureteral contractility rates relative to DMSO controls. The average percent decrease was 43.7% by 100 nM, 66.9% by 1 μM, and 66% by 10 μM hydrocortisone. This decrease in ureteral contractility continued to be significant at 120 minutes. In addition, 10 μM and 1 μM hydrocortisone treatment caused a similar reduction in contractility to indomethacin at 120 minutes. Conclusion: Hydrocortiosone effectively inhibits stretch-induced ureteral contractility of porcine ureter in an isolated in vitro assay." @default.
- W2088513628 created "2016-06-24" @default.
- W2088513628 creator A5003175894 @default.
- W2088513628 creator A5039196990 @default.
- W2088513628 creator A5063164428 @default.
- W2088513628 creator A5077067684 @default.
- W2088513628 creator A5091149781 @default.
- W2088513628 date "2008-06-01" @default.
- W2088513628 modified "2023-10-17" @default.
- W2088513628 title "<i>Third Prize:</i> Effect of Hydrocortisone on Porcine Ureteral Contractility <i>in Vitro</i>" @default.
- W2088513628 cites W1587189580 @default.
- W2088513628 cites W1924092238 @default.
- W2088513628 cites W1970717513 @default.
- W2088513628 cites W1971710614 @default.
- W2088513628 cites W1972077492 @default.
- W2088513628 cites W1984780926 @default.
- W2088513628 cites W1984969043 @default.
- W2088513628 cites W1995158841 @default.
- W2088513628 cites W2013143651 @default.
- W2088513628 cites W2014114206 @default.
- W2088513628 cites W2019270299 @default.
- W2088513628 cites W2025325421 @default.
- W2088513628 cites W2027456692 @default.
- W2088513628 cites W2032174947 @default.
- W2088513628 cites W2039709489 @default.
- W2088513628 cites W2040909007 @default.
- W2088513628 cites W2042988636 @default.
- W2088513628 cites W2064914177 @default.
- W2088513628 cites W2065332962 @default.
- W2088513628 cites W2065866797 @default.
- W2088513628 cites W2067443585 @default.
- W2088513628 cites W2068982512 @default.
- W2088513628 cites W2072205750 @default.
- W2088513628 cites W2081822067 @default.
- W2088513628 cites W2090268015 @default.
- W2088513628 cites W2091363706 @default.
- W2088513628 cites W2099861766 @default.
- W2088513628 cites W2111117392 @default.
- W2088513628 cites W2118844422 @default.
- W2088513628 cites W2132633916 @default.
- W2088513628 cites W2138821085 @default.
- W2088513628 cites W2139965240 @default.
- W2088513628 cites W2140555948 @default.
- W2088513628 cites W2153442708 @default.
- W2088513628 cites W2165502691 @default.
- W2088513628 cites W2171512008 @default.
- W2088513628 cites W2340504819 @default.
- W2088513628 cites W2345961594 @default.
- W2088513628 cites W4230444024 @default.
- W2088513628 doi "https://doi.org/10.1089/end.2008.0072" @default.
- W2088513628 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18484887" @default.
- W2088513628 hasPublicationYear "2008" @default.
- W2088513628 type Work @default.
- W2088513628 sameAs 2088513628 @default.
- W2088513628 citedByCount "5" @default.
- W2088513628 countsByYear W20885136282012 @default.
- W2088513628 countsByYear W20885136282014 @default.
- W2088513628 countsByYear W20885136282016 @default.
- W2088513628 crossrefType "journal-article" @default.
- W2088513628 hasAuthorship W2088513628A5003175894 @default.
- W2088513628 hasAuthorship W2088513628A5039196990 @default.
- W2088513628 hasAuthorship W2088513628A5063164428 @default.
- W2088513628 hasAuthorship W2088513628A5077067684 @default.
- W2088513628 hasAuthorship W2088513628A5091149781 @default.
- W2088513628 hasConcept C126322002 @default.
- W2088513628 hasConcept C126894567 @default.
- W2088513628 hasConcept C134018914 @default.
- W2088513628 hasConcept C163415756 @default.
- W2088513628 hasConcept C2778709874 @default.
- W2088513628 hasConcept C39133596 @default.
- W2088513628 hasConcept C71924100 @default.
- W2088513628 hasConceptScore W2088513628C126322002 @default.
- W2088513628 hasConceptScore W2088513628C126894567 @default.
- W2088513628 hasConceptScore W2088513628C134018914 @default.
- W2088513628 hasConceptScore W2088513628C163415756 @default.
- W2088513628 hasConceptScore W2088513628C2778709874 @default.
- W2088513628 hasConceptScore W2088513628C39133596 @default.
- W2088513628 hasConceptScore W2088513628C71924100 @default.
- W2088513628 hasIssue "6" @default.
- W2088513628 hasLocation W20885136281 @default.
- W2088513628 hasLocation W20885136282 @default.
- W2088513628 hasOpenAccess W2088513628 @default.
- W2088513628 hasPrimaryLocation W20885136281 @default.
- W2088513628 hasRelatedWork W1992418884 @default.
- W2088513628 hasRelatedWork W2027617164 @default.
- W2088513628 hasRelatedWork W2046678612 @default.
- W2088513628 hasRelatedWork W2358369871 @default.
- W2088513628 hasRelatedWork W2369922294 @default.
- W2088513628 hasRelatedWork W2374723269 @default.
- W2088513628 hasRelatedWork W2382983477 @default.
- W2088513628 hasRelatedWork W2748952813 @default.
- W2088513628 hasRelatedWork W2992096461 @default.
- W2088513628 hasRelatedWork W4297461925 @default.
- W2088513628 hasVolume "22" @default.
- W2088513628 isParatext "false" @default.
- W2088513628 isRetracted "false" @default.
- W2088513628 magId "2088513628" @default.
- W2088513628 workType "article" @default.