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• W2088531907 abstract "Background Glutamatergic transmission in the amygdala is hypothesized as an important mediator of stimulus-reward associations contributing to drug-seeking behavior and relapse. Insight is, however, lacking regarding the amygdala glutamatergic system in human drug abusers. Methods We examined glutamate receptors and scaffolding proteins associated with the postsynaptic density in the human postmortem amygdala. Messenger RNA or protein levels were studied in a population of multidrug (seven heroin, eight cocaine, seven heroin/cocaine, and seven controls) or predominant heroin (29 heroin and 15 controls) subjects. Results The amygdala of drug abusers was characterized by a striking positive correlation (r > .8) between α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid glutamate receptor subunit 1 (GluA1) and postsynaptic density protein-95 (PSD-95) mRNA levels, which was not evident in control subjects. Structural equation multigroup analysis of protein correlations also identified the relationship between GluA1 and PSD-95 protein levels as the distinguishing feature of abusers. In line with the GluA1–PSD-95 implications of enhanced synaptic plasticity, Homer 1b/c protein expression was increased in both heroin and cocaine users as was its binding partner, dynamin-3. Furthermore, there was a positive relationship between Homer 1b/c and dynamin-3 in drug abusers that reflected an increase in the direct physical coupling between the proteins. A noted age-related decline of Homer 1b/c–dynamin-3 interactions, as well as GluA1 levels, was blunted in abusers. Conclusions Impairment of key components of the amygdala postsynaptic density and coupling to the endocytic zone, critical for the regulation of glutamate receptor cycling, may underlie heightened synaptic plasticity in human drug abusers. Glutamatergic transmission in the amygdala is hypothesized as an important mediator of stimulus-reward associations contributing to drug-seeking behavior and relapse. Insight is, however, lacking regarding the amygdala glutamatergic system in human drug abusers. We examined glutamate receptors and scaffolding proteins associated with the postsynaptic density in the human postmortem amygdala. Messenger RNA or protein levels were studied in a population of multidrug (seven heroin, eight cocaine, seven heroin/cocaine, and seven controls) or predominant heroin (29 heroin and 15 controls) subjects. The amygdala of drug abusers was characterized by a striking positive correlation (r > .8) between α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid glutamate receptor subunit 1 (GluA1) and postsynaptic density protein-95 (PSD-95) mRNA levels, which was not evident in control subjects. Structural equation multigroup analysis of protein correlations also identified the relationship between GluA1 and PSD-95 protein levels as the distinguishing feature of abusers. In line with the GluA1–PSD-95 implications of enhanced synaptic plasticity, Homer 1b/c protein expression was increased in both heroin and cocaine users as was its binding partner, dynamin-3. Furthermore, there was a positive relationship between Homer 1b/c and dynamin-3 in drug abusers that reflected an increase in the direct physical coupling between the proteins. A noted age-related decline of Homer 1b/c–dynamin-3 interactions, as well as GluA1 levels, was blunted in abusers. Impairment of key components of the amygdala postsynaptic density and coupling to the endocytic zone, critical for the regulation of glutamate receptor cycling, may underlie heightened synaptic plasticity in human drug abusers." @default.
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• W2088531907 date "2011-02-01" @default.
• W2088531907 modified "2023-10-18" @default.
• W2088531907 title "Dysregulated Postsynaptic Density and Endocytic Zone in the Amygdala of Human Heroin and Cocaine Abusers" @default.
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• W2088531907 cites W1628708546 @default.
• W2088531907 cites W1703928766 @default.
• W2088531907 cites W1763958744 @default.
• W2088531907 cites W1946755838 @default.
• W2088531907 cites W1963591499 @default.
• W2088531907 cites W1966013322 @default.
• W2088531907 cites W1966761076 @default.
• W2088531907 cites W1967292256 @default.
• W2088531907 cites W1967880030 @default.
• W2088531907 cites W1976097422 @default.
• W2088531907 cites W1977313055 @default.
• W2088531907 cites W1979956204 @default.
• W2088531907 cites W1985241009 @default.
• W2088531907 cites W1986364137 @default.
• W2088531907 cites W1987174315 @default.
• W2088531907 cites W1997282555 @default.
• W2088531907 cites W2001232602 @default.
• W2088531907 cites W2001797086 @default.
• W2088531907 cites W2003010986 @default.
• W2088531907 cites W2007653857 @default.
• W2088531907 cites W2018177327 @default.
• W2088531907 cites W2019873695 @default.
• W2088531907 cites W2027184260 @default.
• W2088531907 cites W2037836204 @default.
• W2088531907 cites W2042529649 @default.
• W2088531907 cites W2042651745 @default.
• W2088531907 cites W2052599760 @default.
• W2088531907 cites W2068240232 @default.
• W2088531907 cites W2069164790 @default.
• W2088531907 cites W2084700523 @default.
• W2088531907 cites W2085015211 @default.
• W2088531907 cites W2086499290 @default.
• W2088531907 cites W2091402383 @default.
• W2088531907 cites W2093573816 @default.
• W2088531907 cites W2094284473 @default.
• W2088531907 cites W2106719141 @default.
• W2088531907 cites W2113691669 @default.
• W2088531907 cites W2114187641 @default.
• W2088531907 cites W2116342741 @default.
• W2088531907 cites W2126440176 @default.
• W2088531907 cites W2135432300 @default.
• W2088531907 cites W2146326162 @default.
• W2088531907 cites W2157301095 @default.
• W2088531907 cites W2158553737 @default.
• W2088531907 cites W2159640654 @default.
• W2088531907 cites W2162400338 @default.
• W2088531907 cites W2734437822 @default.
• W2088531907 cites W3103710998 @default.
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• W2088531907 doi "https://doi.org/10.1016/j.biopsych.2010.09.037" @default.
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