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- W2088534552 abstract "A novel acetylcholine radioanalog, N-methyl-3-(1-hydroxy-5-[ 123 I]iodopent-4-enyl)-4-acetoxypiperidine, was prepared by radioiodination of the corresponding tributylstannyl precursor that was synthesized in eight steps from 4-piperidone. The tracer has three asymmetric carbons giving eight optical isomers. Two optical isomers were isolated in the precursor synthesis by diastereomeric and enantiomeric separation. In the incubation experiments using rat cerebral cortical homogenate, one optical isomer was hydrolyzed by acetylcholinesterase with high reactivity and selectivity. The tracer is a candidate for mapping cerebral regional acetylcholinesterase activity by single photon emission computed tomography." @default.
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- W2088534552 date "2000-01-01" @default.
- W2088534552 modified "2023-09-24" @default.
- W2088534552 title "N-methyl-3-(1-hydroxy-5-[123I]iodopent-4-enyl)-4-acetoxypiperidine, a novel candidate of acetylcholinesterase activity imaging agent" @default.
- W2088534552 doi "https://doi.org/10.1002/1099-1344(200007)43:8<753::aid-jlcr359>3.0.co;2-#" @default.
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