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• W2088545066 abstract "Imperatorin (Imp) as a hypotensive active ingredient, its hypotensive effect was evaluated in the SHRs, its calcium antagonism and affinity to L-type calcium channel was also confirmed. The results showed that the blood pressure was decreased in the SHRs treated with Imp, the aortic ring was relaxed with Imp, L-type calcium channel currents and intracellular calcium free ion rise was nearly disappeared when adding Imp. In addition, Imp displayed a chromatographic peak similar to nitrendipine and verapamil by the cell membrane chromatography, same results from protein-drug docking approaches. Hence, Imp target the L-type calcium channel, and may be used as a novel antihypertensive drug." @default.
• W2088545066 created "2016-06-24" @default.
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• W2088545066 date "2011-10-01" @default.
• W2088545066 modified "2023-09-26" @default.
• W2088545066 title "A potential calcium antagonist and its antihypertensive effects" @default.
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• W2088545066 doi "https://doi.org/10.1016/j.fitote.2011.05.016" @default.
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