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- W2088551409 abstract "We measured the release of the lysosomal enzymes β-glucuronidase and aryl sulfatase A into lung lymph and plasma after Escherichia coli endotoxin and compared these changes with the pulmonary vascular injury produced. We used 18 unanesthetized sheep, infusing doses of endotoxin from 1 to 10 αg/kg. We identified an early injury phase characterized by severe pulmonary hypertension, a three- to fivefold increase in protein-poor lung lymph flow, and a marked decrease in blood leukocyte count. This was followed several hours later by an increase in vascular permeability with a three- to fivefold increase in protein-rich lung lymph. Lymph lysosomal enzymes increased 200–800% over baseline with a sharp increase occuring during the early hypertension phase. Lymph β-glucuronidase correlated well with the change in vascular permeability measured by lymph flow, r = 0.7. Plasma enzyme values increased, but to a much lesser degree, correlating poorly, r = 0.2, with the lung injury. However, increases over baseline greater than 200% corresponded into with later systemic shock and mortality. We conclude that lysosomal enzymes are released into the lung after endotoxin, probably from sequestered leukocytes, with the degree of release corresponding to the degree of vascular injury." @default.
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- W2088551409 date "1981-02-01" @default.
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- W2088551409 title "Lung injury and lung lysosomal enzyme release during endotoxemia" @default.
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- W2088551409 doi "https://doi.org/10.1016/0022-4804(81)90005-6" @default.
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