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- W2088554384 abstract "High intrathecal levels of anti-myelin basic protein (MBP) IgM were previously found to be significantly associated with early favorable course in a cohort of patients with multiple sclerosis (MS). A mAb to MBP 105–120 recognizing the 222–228 epitope of the extracellular domain of high affinity immunoglobulin gamma Fc-receptor I (CD64) was isolated from EBV+ B cell clones of long-term stable RRMS patients. This mAb exerted immunosuppressive activity on MS-derived T cell lines through induction and release of high amounts of interleukin-10 and decreased levels of interleukin-12 from activated monocytes providing the biological basis for a potential new treatment for MS and other immune-mediated neurological disorders." @default.
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- W2088554384 date "2013-03-01" @default.
- W2088554384 modified "2023-09-23" @default.
- W2088554384 title "Immunosuppressive monoclonal antibody to CD64 from patients with long-term stable multiple sclerosis" @default.
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- W2088554384 doi "https://doi.org/10.1016/j.jneuroim.2012.12.007" @default.
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