FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088557075> ?p ?o ?g. }

• W2088557075 endingPage "e100178" @default.
• W2088557075 startingPage "e100178" @default.
• W2088557075 abstract "CSPG4 marks pericytes, undifferentiated precursors and tumor cells. We assessed whether the shed ectodomain of CSPG4 (sCSPG4) might circulate and reflect potential changes in CSPG4 tissue expression (pCSPG4) due to desmoplastic and malignant aberrations occurring in pancreatic tumors. Serum sCSPG4 was measured using ELISA in test (n = 83) and validation (n = 221) cohorts comprising donors (n = 11+26) and patients with chronic pancreatitis (n = 11+20) or neoplasms: benign (serous cystadenoma SCA, n = 13+20), premalignant (intraductal dysplastic IPMNs, n = 9+55), and malignant (IPMN-associated invasive carcinomas, n = 4+14; ductal adenocarcinomas, n = 35+86). Pancreatic pCSPG4 expression was evaluated using qRT-PCR (n = 139), western blot analysis and immunohistochemistry. sCSPG4 was found in circulation, but its level was significantly lower in pancreatic patients than in donors. Selective maintenance was observed in advanced IPMNs and PDACs and showed a nodal association while lacking prognostic relevance. Pancreatic pCSPG4 expression was preserved or elevated, whereby neoplastic cells lacked pCSPG4 or tended to overexpress without shedding. Extreme pancreatic overexpression, membranous exposure and tissuehigh/seralow-discordance highlighted stroma-poor benign cystic neoplasm. SCA is known to display hypoxic markers and coincide with von-Hippel-Lindau and Peutz-Jeghers syndromes, in which pVHL and LBK1 mutations affect hypoxic signaling pathways. In vitro testing confined pCSPG4 overexpression to normal mesenchymal but not epithelial cells, and a third of tested carcinoma cell lines; however, only the latter showed pCSPG4-responsiveness to chronic hypoxia. siRNA-based knockdowns failed to reduce the malignant potential of either normoxic or hypoxic cells. Thus, overexpression of the newly established conditional hypoxic indicator, CSPG4, is apparently non-pathogenic in pancreatic malignancies but might mark distinct epithelial lineage and contribute to cell polarity disorders. Surficial retention on tumor cells renders CSPG4 an attractive therapeutic target. Systemic ‘drop and restoration’ alterations accompanying IPMN and PDAC progression indicate that the interference of pancreatic diseases with local and remote shedding/release of sCSPG4 into circulation deserves broad diagnostic exploration." @default.
• W2088557075 created "2016-06-24" @default.
• W2088557075 creator A5012385140 @default.
• W2088557075 creator A5013838341 @default.
• W2088557075 creator A5041359420 @default.
• W2088557075 creator A5044899355 @default.
• W2088557075 creator A5048594071 @default.
• W2088557075 creator A5055821992 @default.
• W2088557075 creator A5067125554 @default.
• W2088557075 creator A5070027273 @default.
• W2088557075 creator A5082559565 @default.
• W2088557075 creator A5087399868 @default.
• W2088557075 date "2014-06-16" @default.
• W2088557075 modified "2023-09-26" @default.
• W2088557075 title "Chondroitin Sulfate Proteoglycan CSPG4 as a Novel Hypoxia-Sensitive Marker in Pancreatic Tumors" @default.
• W2088557075 cites W1551006141 @default.
• W2088557075 cites W1562790090 @default.
• W2088557075 cites W1602215762 @default.
• W2088557075 cites W1967197732 @default.
• W2088557075 cites W1969717583 @default.
• W2088557075 cites W1969831578 @default.
• W2088557075 cites W1971003402 @default.
• W2088557075 cites W1971689970 @default.
• W2088557075 cites W1972841928 @default.
• W2088557075 cites W1977629656 @default.
• W2088557075 cites W1977907658 @default.
• W2088557075 cites W1978216398 @default.
• W2088557075 cites W1980332290 @default.
• W2088557075 cites W1992824416 @default.
• W2088557075 cites W1993922189 @default.
• W2088557075 cites W1998664010 @default.
• W2088557075 cites W1999235323 @default.
• W2088557075 cites W1999980448 @default.
• W2088557075 cites W2009976397 @default.
• W2088557075 cites W2010974685 @default.
• W2088557075 cites W2014087908 @default.
• W2088557075 cites W2014782980 @default.
• W2088557075 cites W2027550738 @default.
• W2088557075 cites W2027852965 @default.
• W2088557075 cites W2029452593 @default.
• W2088557075 cites W2045356233 @default.
• W2088557075 cites W2048253455 @default.
• W2088557075 cites W2059700587 @default.
• W2088557075 cites W2065725084 @default.
• W2088557075 cites W2067495748 @default.
• W2088557075 cites W2071944097 @default.
• W2088557075 cites W2072525040 @default.
• W2088557075 cites W2073290778 @default.
• W2088557075 cites W2079043489 @default.
• W2088557075 cites W2079791201 @default.
• W2088557075 cites W2087276195 @default.
• W2088557075 cites W2090803746 @default.
• W2088557075 cites W2093450947 @default.
• W2088557075 cites W2101584437 @default.
• W2088557075 cites W2106210309 @default.
• W2088557075 cites W2119578188 @default.
• W2088557075 cites W2120259831 @default.
• W2088557075 cites W2131070390 @default.
• W2088557075 cites W2132387165 @default.
• W2088557075 cites W2133154776 @default.
• W2088557075 cites W2141605081 @default.
• W2088557075 cites W2143291443 @default.
• W2088557075 cites W2145604739 @default.
• W2088557075 cites W2146037272 @default.
• W2088557075 cites W2148560417 @default.
• W2088557075 cites W2154790710 @default.
• W2088557075 cites W2157212892 @default.
• W2088557075 cites W2157739976 @default.
• W2088557075 cites W2165079404 @default.
• W2088557075 cites W2166228934 @default.
• W2088557075 cites W2172729880 @default.
• W2088557075 cites W2397945685 @default.
• W2088557075 cites W2551569844 @default.
• W2088557075 cites W91126227 @default.
• W2088557075 doi "https://doi.org/10.1371/journal.pone.0100178" @default.
• W2088557075 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4059742" @default.
• W2088557075 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24932730" @default.
• W2088557075 hasPublicationYear "2014" @default.
• W2088557075 type Work @default.
• W2088557075 sameAs 2088557075 @default.
• W2088557075 citedByCount "21" @default.
• W2088557075 countsByYear W20885570752015 @default.
• W2088557075 countsByYear W20885570752017 @default.
• W2088557075 countsByYear W20885570752018 @default.
• W2088557075 countsByYear W20885570752019 @default.
• W2088557075 countsByYear W20885570752021 @default.
• W2088557075 countsByYear W20885570752022 @default.
• W2088557075 countsByYear W20885570752023 @default.
• W2088557075 crossrefType "journal-article" @default.
• W2088557075 hasAuthorship W2088557075A5012385140 @default.
• W2088557075 hasAuthorship W2088557075A5013838341 @default.
• W2088557075 hasAuthorship W2088557075A5041359420 @default.
• W2088557075 hasAuthorship W2088557075A5044899355 @default.
• W2088557075 hasAuthorship W2088557075A5048594071 @default.
• W2088557075 hasAuthorship W2088557075A5055821992 @default.
• W2088557075 hasAuthorship W2088557075A5067125554 @default.
• W2088557075 hasAuthorship W2088557075A5070027273 @default.
• W2088557075 hasAuthorship W2088557075A5082559565 @default.

• next