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- W2088557746 abstract "We have studied genetic variation for levels of activity of the enzyme superoxide dismutase (SOD) in Drosophila melanogaster. We have constructed 34 lines homozygous for a given second and a given third chromosome derived from eight original lines; all lines were homozygous for the “fast” (F) allele of Sod. The variation in the relative levels of SOD CRM ranges from 1 to 1.6. The second chromosomes modify the SOD level, even though the structural Sod locus is in the third chromosome, and the specific effect of a given second chromosome depends on the particular third chromosome with which it is combined. This indicates that the variation in SOD content is controlled by polygenic modifiers present in the second (and in the third) chromosome. In addition to these trans-acting modifiers, we have isolated a cis-acting element (Sod CAl ) that reduces SOD CRM levels to 3.5% of a typical F/F homozygote. Sod CAl is either a mutation in a regulatory site closely linked to the structural locus or a change in the coding sequence affecting the rate of degradation of the enzyme." @default.
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- W2088557746 date "1986-04-01" @default.
- W2088557746 modified "2023-09-27" @default.
- W2088557746 title "Genetic variation for superoxide dismutase level in Drosophila melanogaster" @default.
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- W2088557746 doi "https://doi.org/10.1007/bf00502785" @default.
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