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• W2088561619 endingPage "2283" @default.
• W2088561619 startingPage "2275" @default.
• W2088561619 abstract "The prevention of nonspecific protein adsorption is a crucial prerequisite for many biomedical and biotechnological applications. Therefore, the design of robust and versatile methods conferring optimal protein-resistance properties to surfaces has become a challenging issue. Here we report the unexpected case of polycation-ending polyelectrolyte multilayers (PEM) that efficiently prevented the adsorption of a negatively charged model protein, glucose oxidase (GOX). PEM films were based on two typical weak poyelectrolytes: poly(allylamine hydrochloride) (PAH) and poly(acrylic acid) (PAA). No chemical modification of the polyelectrolytes was required and tunable GOX adsorption was possible by simply changing the buildup pH conditions. Protein-resistance properties are attributed to high film hydration becoming the predominant factor over electrostatic interactions. We explain this effect by oscillations of the internal PAA ionization state throughout the buildup, which results in an excess of carboxylic acid groups within the film. This excess acts as a reservoir of potential carboxylate groups compensating the outer PAH positive charges. Partial results indicated that the system was also resistant to the adsorption of a positively charged protein, lysozyme. Control of the internal ionization of weak polyelectrolyte multilayers might open a route toward simple tuning of protein adsorption. These results should help to rationalize the design of biomaterials, biosensors, or protein separation devices." @default.
• W2088561619 created "2016-06-24" @default.
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• W2088561619 date "2009-07-20" @default.
• W2088561619 modified "2023-09-30" @default.
• W2088561619 title "Tunable Protein-Resistance of Polycation-Terminated Polyelectrolyte Multilayers" @default.
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• W2088561619 doi "https://doi.org/10.1021/bm900453s" @default.
• W2088561619 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19618907" @default.
• W2088561619 hasPublicationYear "2009" @default.
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