FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088561818> ?p ?o ?g. }

• W2088561818 endingPage "2997" @default.
• W2088561818 startingPage "2983" @default.
• W2088561818 abstract "Screening patients at high risk of recurrence of cancer would allow for more accurate and personalized treatment. In this study, we tried to identify the prognosis-related protein profile by applying two different quantitative proteomic techniques, difference in-gel electrophoresis and cleavable isotope-coded affinity tag method. Six tumor tissues were obtained from stage IV colorectal cancer (CRC) patients, of which three have survived more than five years (good prognostic group, GPG) and the other three died within 25 months (poor prognostic group, PPG) after palliative surgery and subsequent chemotherapy treatment. From the two independent quantitative analyses, we identified 175 proteins with abundance ratios greater than 2-fold. Gene ontology analysis revealed that proteins related to cellular assembly/organization and movement were generally increased in the PPG. Twenty-two proteins, including caveolin-1, were chosen for confirmatory studies by Western blot and immunohistochemistry. The Western blot data for each individual protein were analyzed with Mann–Whitney tests, and a multi-marker panel was generated by logistic regression analysis. Five proteins, fatty acid binding protein 1, intelectin 1, transitional endoplasmic reticulum ATPase, transgelin and tropomyosin 2, were significantly different between the two prognostic groups within 95% confidence. No single protein could completely distinguish the two groups from each other. However, a combination of the five proteins effectively distinguished PPG from GPG patients (AUC = 1). Our study suggests a multi-marker panel composed of proteome signatures that provide accurate predictive information and potentially assist personalized therapy. This article is part of a Special Issue entitled: Proteomics: The clinical link." @default.
• W2088561818 created "2016-06-24" @default.
• W2088561818 creator A5019627990 @default.
• W2088561818 creator A5026148041 @default.
• W2088561818 creator A5032439705 @default.
• W2088561818 creator A5044783023 @default.
• W2088561818 creator A5057017443 @default.
• W2088561818 creator A5070010238 @default.
• W2088561818 creator A5073500669 @default.
• W2088561818 creator A5086720093 @default.
• W2088561818 date "2012-06-01" @default.
• W2088561818 modified "2023-10-18" @default.
• W2088561818 title "Profiling of differentially expressed proteins in stage IV Colorectal cancers with good and poor outcomes" @default.
• W2088561818 cites W1494846231 @default.
• W2088561818 cites W1518252063 @default.
• W2088561818 cites W1965402114 @default.
• W2088561818 cites W1971804207 @default.
• W2088561818 cites W1976738458 @default.
• W2088561818 cites W1991377157 @default.
• W2088561818 cites W1997458357 @default.
• W2088561818 cites W1999744363 @default.
• W2088561818 cites W2011912935 @default.
• W2088561818 cites W2013586162 @default.
• W2088561818 cites W2016732851 @default.
• W2088561818 cites W2019893869 @default.
• W2088561818 cites W2023351030 @default.
• W2088561818 cites W2026515027 @default.
• W2088561818 cites W2027671252 @default.
• W2088561818 cites W2043103956 @default.
• W2088561818 cites W2046875430 @default.
• W2088561818 cites W2051261215 @default.
• W2088561818 cites W2051609399 @default.
• W2088561818 cites W2058993987 @default.
• W2088561818 cites W2065383116 @default.
• W2088561818 cites W2070842899 @default.
• W2088561818 cites W2072451410 @default.
• W2088561818 cites W2073079990 @default.
• W2088561818 cites W2075736204 @default.
• W2088561818 cites W2077440316 @default.
• W2088561818 cites W2086641174 @default.
• W2088561818 cites W2092024986 @default.
• W2088561818 cites W2096497763 @default.
• W2088561818 cites W2101037339 @default.
• W2088561818 cites W2109826201 @default.
• W2088561818 cites W2111208057 @default.
• W2088561818 cites W2115397673 @default.
• W2088561818 cites W2115884477 @default.
• W2088561818 cites W2116201301 @default.
• W2088561818 cites W2119249620 @default.
• W2088561818 cites W2123538605 @default.
• W2088561818 cites W2135114065 @default.
• W2088561818 cites W2153206163 @default.
• W2088561818 cites W2163839875 @default.
• W2088561818 cites W2170866914 @default.
• W2088561818 cites W1968358740 @default.
• W2088561818 doi "https://doi.org/10.1016/j.jprot.2011.12.002" @default.
• W2088561818 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22178445" @default.
• W2088561818 hasPublicationYear "2012" @default.
• W2088561818 type Work @default.
• W2088561818 sameAs 2088561818 @default.
• W2088561818 citedByCount "40" @default.
• W2088561818 countsByYear W20885618182013 @default.
• W2088561818 countsByYear W20885618182014 @default.
• W2088561818 countsByYear W20885618182015 @default.
• W2088561818 countsByYear W20885618182016 @default.
• W2088561818 countsByYear W20885618182017 @default.
• W2088561818 countsByYear W20885618182018 @default.
• W2088561818 countsByYear W20885618182019 @default.
• W2088561818 countsByYear W20885618182020 @default.
• W2088561818 countsByYear W20885618182021 @default.
• W2088561818 countsByYear W20885618182022 @default.
• W2088561818 countsByYear W20885618182023 @default.
• W2088561818 crossrefType "journal-article" @default.
• W2088561818 hasAuthorship W2088561818A5019627990 @default.
• W2088561818 hasAuthorship W2088561818A5026148041 @default.
• W2088561818 hasAuthorship W2088561818A5032439705 @default.
• W2088561818 hasAuthorship W2088561818A5044783023 @default.
• W2088561818 hasAuthorship W2088561818A5057017443 @default.
• W2088561818 hasAuthorship W2088561818A5070010238 @default.
• W2088561818 hasAuthorship W2088561818A5073500669 @default.
• W2088561818 hasAuthorship W2088561818A5086720093 @default.
• W2088561818 hasConcept C104317684 @default.
• W2088561818 hasConcept C104397665 @default.
• W2088561818 hasConcept C121608353 @default.
• W2088561818 hasConcept C126322002 @default.
• W2088561818 hasConcept C143998085 @default.
• W2088561818 hasConcept C2776415932 @default.
• W2088561818 hasConcept C46111723 @default.
• W2088561818 hasConcept C526805850 @default.
• W2088561818 hasConcept C55493867 @default.
• W2088561818 hasConcept C60644358 @default.
• W2088561818 hasConcept C71924100 @default.
• W2088561818 hasConcept C85265743 @default.
• W2088561818 hasConcept C86803240 @default.
• W2088561818 hasConceptScore W2088561818C104317684 @default.
• W2088561818 hasConceptScore W2088561818C104397665 @default.
• W2088561818 hasConceptScore W2088561818C121608353 @default.
• W2088561818 hasConceptScore W2088561818C126322002 @default.

• next