FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088571284> ?p ?o ?g. }

• W2088571284 endingPage "2042" @default.
• W2088571284 startingPage "2029" @default.
• W2088571284 abstract "Lipid rafts are cholesterol-enriched microdomains involved in cellular trafficking and implicated as portals for certain pathogens. We sought to determine whether the oral pathogen Porphyromonas gingivalis enters macrophages via lipid rafts, and if so, to examine the impact of raft entry on its intracellular fate. Using J774A.1 mouse macrophages, we found that P. gingivalis colocalizes with lipid rafts in a cholesterol-dependent way. Depletion of cellular cholesterol using methyl-beta-cyclodextrin resulted in about 50% inhibition of P. gingivalis uptake, although this effect was reversed by cholesterol reconstitution. The intracellular survival of P. gingivalis was dramatically inhibited in cholesterol-depleted cells relative to untreated or cholesterol-reconstituted cells, even when infections were adjusted to allow equilibration of the initial intracellular bacterial load. P. gingivalis thus appeared to exploit raft-mediated uptake for promoting its survival. Consistent with this, lipid raft disruption enhanced the colocalization of internalized P. gingivalis with lysosomes. In contrast, raft disruption did not affect the expression of host receptors interacting with P. gingivalis, although it significantly inhibited signal transduction. In summary, P. gingivalis uses macrophage lipid rafts as signalling and entry platforms, which determine its intracellular fate to the pathogen's own advantage." @default.
• W2088571284 created "2016-06-24" @default.
• W2088571284 creator A5015102287 @default.
• W2088571284 creator A5084031628 @default.
• W2088571284 date "2008-10-01" @default.
• W2088571284 modified "2023-09-22" @default.
• W2088571284 title "Lipid raft-dependent uptake, signalling and intracellular fate of<i>Porphyromonas gingivalis</i>in mouse macrophages" @default.
• W2088571284 cites W1564861448 @default.
• W2088571284 cites W1579749431 @default.
• W2088571284 cites W1861867405 @default.
• W2088571284 cites W1893408494 @default.
• W2088571284 cites W1964688185 @default.
• W2088571284 cites W1969571975 @default.
• W2088571284 cites W1979680810 @default.
• W2088571284 cites W1986811442 @default.
• W2088571284 cites W1993364469 @default.
• W2088571284 cites W1994878489 @default.
• W2088571284 cites W1996951540 @default.
• W2088571284 cites W1997181834 @default.
• W2088571284 cites W1998025863 @default.
• W2088571284 cites W1998210753 @default.
• W2088571284 cites W2000200572 @default.
• W2088571284 cites W2003405170 @default.
• W2088571284 cites W2006446093 @default.
• W2088571284 cites W2011630686 @default.
• W2088571284 cites W2012416622 @default.
• W2088571284 cites W2020889689 @default.
• W2088571284 cites W2021691735 @default.
• W2088571284 cites W2022497999 @default.
• W2088571284 cites W2025529482 @default.
• W2088571284 cites W2027551392 @default.
• W2088571284 cites W2027855860 @default.
• W2088571284 cites W2033431538 @default.
• W2088571284 cites W2036428031 @default.
• W2088571284 cites W2038713847 @default.
• W2088571284 cites W2044097621 @default.
• W2088571284 cites W2046641769 @default.
• W2088571284 cites W2047836270 @default.
• W2088571284 cites W2056194352 @default.
• W2088571284 cites W2059917547 @default.
• W2088571284 cites W2061677679 @default.
• W2088571284 cites W2063749886 @default.
• W2088571284 cites W2064774008 @default.
• W2088571284 cites W2064990226 @default.
• W2088571284 cites W2075512720 @default.
• W2088571284 cites W2078314435 @default.
• W2088571284 cites W2081359143 @default.
• W2088571284 cites W2084250362 @default.
• W2088571284 cites W2084510651 @default.
• W2088571284 cites W2088618181 @default.
• W2088571284 cites W2092032357 @default.
• W2088571284 cites W2092703416 @default.
• W2088571284 cites W2096878710 @default.
• W2088571284 cites W2097181782 @default.
• W2088571284 cites W2098065055 @default.
• W2088571284 cites W2099988624 @default.
• W2088571284 cites W2103601881 @default.
• W2088571284 cites W2113949809 @default.
• W2088571284 cites W2114224063 @default.
• W2088571284 cites W2117845905 @default.
• W2088571284 cites W2121936687 @default.
• W2088571284 cites W2122310864 @default.
• W2088571284 cites W2124974603 @default.
• W2088571284 cites W2130388575 @default.
• W2088571284 cites W2131970063 @default.
• W2088571284 cites W2132019676 @default.
• W2088571284 cites W2133664523 @default.
• W2088571284 cites W2137401408 @default.
• W2088571284 cites W2144789639 @default.
• W2088571284 cites W2144877467 @default.
• W2088571284 cites W2155099281 @default.
• W2088571284 cites W2158754447 @default.
• W2088571284 cites W2159908078 @default.
• W2088571284 cites W2170863757 @default.
• W2088571284 doi "https://doi.org/10.1111/j.1462-5822.2008.01185.x" @default.
• W2088571284 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2670473" @default.
• W2088571284 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18547335" @default.
• W2088571284 hasPublicationYear "2008" @default.
• W2088571284 type Work @default.
• W2088571284 sameAs 2088571284 @default.
• W2088571284 citedByCount "64" @default.
• W2088571284 countsByYear W20885712842012 @default.
• W2088571284 countsByYear W20885712842013 @default.
• W2088571284 countsByYear W20885712842014 @default.
• W2088571284 countsByYear W20885712842015 @default.
• W2088571284 countsByYear W20885712842016 @default.
• W2088571284 countsByYear W20885712842017 @default.
• W2088571284 countsByYear W20885712842018 @default.
• W2088571284 countsByYear W20885712842019 @default.
• W2088571284 countsByYear W20885712842020 @default.
• W2088571284 countsByYear W20885712842021 @default.
• W2088571284 countsByYear W20885712842022 @default.
• W2088571284 countsByYear W20885712842023 @default.
• W2088571284 crossrefType "journal-article" @default.
• W2088571284 hasAuthorship W2088571284A5015102287 @default.
• W2088571284 hasAuthorship W2088571284A5084031628 @default.
• W2088571284 hasBestOaLocation W20885712841 @default.
• W2088571284 hasConcept C15920480 @default.

• next