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- W2088578637 abstract "To assess the diffusion of gonadotropin into the follicular fluid (FF) and its relation to the results achieved in a human IVF-ET program.Retrospective pharmacokinetic study.Fukuoka University Hospital, Japan.Eighty-seven infertile patients underwent 137 cycles of IVF-ET.Serum and FF were collected at the time of oocyte recovery. The hCG ratio (between follicular hCG and serum hCG concentrations, measured by time-resolved fluoroimmunoassay) was evaluated as an index of the diffusion of exogenous gonadotropin.Relation between hCG ratio and the results and outcome of the IVF-ET program.The hCG ratio decreased with the total dosage of hMG and increased with the serum E2 level, the number of oocytes recovered, and the number of oocytes fertilized. Patients with a poor response showed a low hCG ratio, which was associated with a complete lack of fertilization. The mean hCG ratio in the pregnant cycles was significantly higher than that in the nonpregnant cycles. An hCG ratio > 0.46 was seen in all pregnant cycles.The diffusion of exogenous gonadotropin into the FF may be an important predictor of IVF outcome." @default.
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- W2088578637 date "1999-08-01" @default.
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- W2088578637 title "Pharmacokinetics of exogenous gonadotropin and ovarian response in in vitro fertilization" @default.
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- W2088578637 doi "https://doi.org/10.1016/s0015-0282(99)00228-9" @default.
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